Skip to content

rabbit anti-DR3 (CT) polyclonal antibody 5310

$445.00

Antibody summary

  • Rabbit polyclonal to DR3 (CT)
  • Suitable for: ELISA,WB,IF
  • Isotype: IgG
  • 100 µg
SKU: 5310parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

rabbit

isotype

IgG

clonality

polyclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

DR3 (CT)

available sizes

100 µg

Available product – rabbit anti-DR3 (CT) polyclonal antibody 5310

antibody
Tested applications
WB,ICC/IF,ELISA
Recommended dilutions
Immunoblotting: use at 2ug/mL.

Positive control: Whole cell lysate from Jurkat cells.

These are recommended concentrations.

Enduser should determine optimal concentrations for their applications.
Immunogen
Peptide corresponding to aa 398-417 of human DR3 (accession no. AAQ88676).
Size and concentration
100µg and lot specific
Form
liquid
Storage Instructions
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Storage buffer
PBS, pH 7.4.
Purity
peptide affinty purifcation
Clonality
polyclonal
Isotype
IgG
Compatible secondaries
goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863
goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371
goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715
goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control
Rabbit polyclonal - Isotype Control
target relevance
Protein names
Tumor necrosis factor receptor superfamily member 25 (Apo-3) (Apoptosis-inducing receptor AIR) (Apoptosis-mediating receptor DR3) (Apoptosis-mediating receptor TRAMP) (Death receptor 3) (Lymphocyte-associated receptor of death) (LARD) (Protein WSL) (Protein WSL-1)
Gene names
TNFRSF25,TNFRSF25 APO3 DDR3 DR3 TNFRSF12 WSL WSL1 UNQ455/PRO779
Mass
45385Da
Function
FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. {ECO:0000269|PubMed:8875942, ECO:0000269|PubMed:8994832, ECO:0000269|PubMed:9052839}.
Subellular location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted.
Tissues
TISSUE SPECIFICITY: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate.
Structure
SUBUNIT: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. {ECO:0000269|PubMed:9915703}.
Post-translational modification
PTM: (Microbial infection) Glycosylated at Arg-352 by enteropathogenic E.coli protein NleB1. {ECO:0000305|PubMed:30979585}.; PTM: Glycosylated. {ECO:0000305}.
Domain
TOPO_DOM 2
Target Relevance information above includes information from UniProt accession : Q93038
The UniProt Consortium

Data

benchmark-antibodies_anti-dr3_ct_antibody_5310_1.jpg
Western blot analysis of DR3 in Jurkat total cell lysate with DR3 antibody at 1:500 dilution.
benchmark-antibodies_anti-dr3_ct_antibody_5310_2.gif
Immunofluorescence of DR3 in Jurkat cells with DR3 antibody at 20 µg/mL. Green: DR3 Antibody (5310)
Blue: DAPI staining

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

#
No results found

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.