| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | rabbit |
| isotype | IgG |
| clonality | polyclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Cyclin E1 |
| available sizes | 100 µg |
rabbit anti-Cyclin E1 polyclonal antibody 5435
$376.00
Antibody summary
- Rabbit polyclonal to Cyclin E1
- Suitable for: ELISA
- Isotype: Whole IgG
- 100 µg
rabbit anti-Cyclin E1 polyclonal antibody 5435
| target relevance |
|---|
| Protein names G1/S-specific cyclin-E1 |
| Gene names CCNE1,CCNE1 CCNE |
| Protein family Cyclin family, Cyclin E subfamily |
| Mass 47077Da |
| Function Essential for the control of the cell cycle at the G1/S (start) transition. |
| Subellular location Nucleus . |
| Tissues Highly expressed in testis and placenta. Low levels in bronchial epithelial cells. |
| Structure Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187). |
| Post-translational modification Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.; Ubiquitinated by UHRF2; appears to occur independently of phosphorylation. |
| Target Relevance information above includes information from UniProt accession: P24864 |
| The UniProt Consortium |
Data
| No results found |
Publications
Publications
| pmid | title | authors | citation |
|---|---|---|---|
| We haven't added any publications to our database yet. | |||
Protocols
| relevant to this product |
|---|
| ELISA |
Documents
| # | SDS | Certificate | |
|---|---|---|---|
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