| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | rabbit |
| isotype | IgG |
| clonality | polyclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Chemoattractant Receptor Homologus molecule (CRTH2) |
| available sizes | 100 µg |
rabbit anti-CRTH2 polyclonal antibody 6812
$376.00
Antibody summary
- Rabbit polyclonal to CRTH2
- Suitable for: WB
- Isotype: Whole IgG
- 100 µg
rabbit anti-CRTH2 polyclonal antibody 6812
| target relevance |
|---|
| Protein names Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294) |
| Gene names PTGDR2,PTGDR2 CRTH2 DL1R GPR44 |
| Protein family G-protein coupled receptor 1 family |
| Mass 43268Da |
| Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. |
| Subellular location Cell membrane ; Multi-pass membrane protein. Note=Internalized receptors colocalized with RAB11A. |
| Tissues Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. |
| Post-translational modification Phosphorylated. |
| Domain TOPO_DOM 1 |
| Target Relevance information above includes information from UniProt accession: Q9Y5Y4 |
| The UniProt Consortium |
Data
| No results found |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
|---|
Protocols
| relevant to this product |
|---|
| Western blot IHC ICC |
Documents
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| Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. | |||
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