Name: rabbit anti-CRTH2 polyclonal antibody 6812
SKU: 6812parent
Price: 376.00 USD
Availability: InStock

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	rabbit
isotype	IgG
clonality	polyclonal
concentration	1 mg/mL
applications	ICC/IF, WB
reactivity	Chemoattractant Receptor Homologus molecule (CRTH2)
available sizes	100 µg

rabbit anti-CRTH2 polyclonal antibody 6812

antibody

Tested applications WB
Recommended dilutions Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 55-70 kD is detected.
Immunogen Human CRTH2 protein.
Size and concentration 100µg and lot specific
Form liquid
Storage Instructions This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Storage buffer PBS, pH 7.4.
Purity immunogen affinty purifcation
Clonality polyclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Prostaglandin D2 receptor 2 (Chemoattractant receptor-homologous molecule expressed on Th2 cells) (G-protein coupled receptor 44) (CD antigen CD294)
Gene names PTGDR2,PTGDR2 CRTH2 DL1R GPR44
Protein family G-protein coupled receptor 1 family
Mass 43268Da
Function FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269\|PubMed:11208866, ECO:0000269\|PubMed:11535533, ECO:0000269\|PubMed:17196174}.
Subellular location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269\|PubMed:17207480}.
Tissues TISSUE SPECIFICITY: Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269\|PubMed:11168006, ECO:0000269\|PubMed:11208866, ECO:0000269\|PubMed:12466225, ECO:0000269\|PubMed:9973380}.
Post-translational modification PTM: Phosphorylated. {ECO:0000269\|PubMed:17207480}.
Domain TOPO_DOM 1
Target Relevance information above includes information from UniProt accession : Q9Y5Y4
The UniProt Consortium

Data

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Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmid	title	authors	citation

Protocols

relevant to this product
Western blot IHC ICC

Documents

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