| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | mouse |
| isotype | IgG1 |
| clonality | monoclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Cardiac Troponin T |
| available sizes | 100 µg |
mouse anti-Cardiac Tropinin T monoclonal antibody (1C11) 9482
$235.00
Antibody summary
- Mouse monoclonal to Cardiac Tropinin T
- Suitable for: ELISA
- Isotype: IgG1
- 100 µg
mouse anti-Cardiac Tropinin T monoclonal antibody (1C11) 9482
| antibody |
|---|
| Tested applications ELISA |
| Recommended dilutions These antibodies may be used in immunoassays to detect and quantitate human cardiac troponin T. They may also be used to affinity purify cardiac troponin T. |
| Immunogen Purified human cardiac troponin T. |
| Size and concentration 100µg and lot specific |
| Form liquid |
| Storage Instructions These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles. |
| Storage buffer PBS containing 0.1% NaN3 |
| Purity protein affinty purification |
| Clonality monoclonal |
| Isotype IgG1 |
| Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721 |
| Isotype control Mouse monocolonal IgG1 - Isotype Control |
| target relevance |
|---|
| Protein names Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT) |
| Gene names TNNT2,TNNT2 |
| Protein family Troponin T family |
| Mass 35924Da |
| Function Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Tissues Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. |
| Post-translational modification Phosphorylation at Thr-213 by PRKCA induces significant reduction in myofilament calcium sensitivity and actomyosin ATPase activity. |
| Involvement in disease DISEASE: Cardiomyopathy, familial hypertrophic, 2 (CMH2) [MIM:115195]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, dilated, 1D (CMD1D) [MIM:601494]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial restrictive 3 (RCM3) [MIM:612422]: A heart disorder characterized by impaired filling of the ventricles with reduced diastolic volume, in the presence of normal or near normal wall thickness and systolic function. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Target Relevance information above includes information from UniProt accession: P45379 |
| The UniProt Consortium |
Data
| No results found |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.There are 242 publications in our database for this antibody or clone. Here are the latest 5, for more click below.
| pmid | title | authors | citation |
|---|---|---|---|
| 36499727 | INO80 Is Required for the Cell Cycle Control, Survival, and Differentiation of Mouse ESCs by Transcriptional Regulation | Yoo S, Lee EJ, Thang NX, La H, Lee H, Park C, Han DW, Uhm SJ, Song H, Do JT, Choi Y, Hong K. | Int J Mol Sci. 2022 Dec 6;23(23):15402. doi: 10.3390/ijms232315402. |
| 36438566 | Immunosuppressants Tacrolimus and Sirolimus revert the cardiac antifibrotic properties of p38-MAPK inhibition in 3D-multicellular human iPSC-heart organoids | Tian Y, Tsujisaka Y, Li VY, Tani K, Lucena-Cacace A, Yoshida Y. | Front Cell Dev Biol. 2022 Nov 11;10:1001453. doi: 10.3389/fcell.2022.1001453. eCollection 2022. |
| 36335128 | Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction | Zhou X, Zhang C, Wu X, Hu X, Zhang Y, Wang X, Zheng L, Gao P, Du J, Zheng W, Shang H, Hu K, Jiang Z, Nie Y, Hu S, Xiao RP, Zhu X, Xiong JW. | Nat Commun. 2022 Nov 5;13(1):6672. doi: 10.1038/s41467-022-33631-z. |
| 36147944 | A scalable and tunable thermoreversible polymer for 3D human pluripotent stem cell biomanufacturing | Johnson HJ, Chakraborty S, Muckom RJ, Balsara NP, Schaffer DV. | iScience. 2022 Aug 25;25(10):104971. doi: 10.1016/j.isci.2022.104971. eCollection 2022 Oct 21. |
| 36082129 | CDK9 binds and activates SGK3 to promote cardiac repair after injury via the GSK-3β/β-catenin pathway | Sun J, Yang T, Wei T, Zhou L, Shan T, Chen J, Gu L, Chen B, Liu L, Jiang Q, Du C, Ma Y, Wang H, Chen F, Guo X, Ji Y, Wang L. | Front Cardiovasc Med. 2022 Aug 23;9:970745. doi: 10.3389/fcvm.2022.970745. eCollection 2022. |
Protocols
| relevant to this product |
|---|
| ELISA |
Documents
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| Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. | |||
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