| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Herpes Simplex Virus 1+2 reactive IgA |
| species reactivity | Herpes Simplex Virus |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available size | 3 mL |
Herpes Simplex Virus 1+2 IgA Control Serum BC105A
$94.00
Summary
- Virion/Serion Diagnostic Kit Control for research use (RUO)
- Herpes Simplex Virus (HSV) 1+2 IgA Control Serum
- Applications: ELISA
- IgA control serum
- Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
- 3 mL
Herpes Simplex Virus 1+2 IgA Control Serum BC105A
| target relevance |
|---|
| Organism Herpes Simplex Virus 1/2 |
| Structure and strains Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known by their taxonomic names Human alphaherpesvirus 1 and Human alphaherpesvirus 2, are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Both HSV-1 and HSV-2 are very common and contagious. They can be spread when an infected person begins shedding the virus. As of 2016, about 67% of the world population under the age of 50 had HSV-1. In the United States, about 47.8% and 11.9% are estimated to have HSV-1 and HSV-2, respectively, though actual prevalence may be much higher. Because it can be transmitted through any intimate contact, it is one of the most common sexually transmitted infections. |
| Disease Herpes Simplex Virus 1 (HSV 1) and Herpes Simplex Virus 2 (HSV 2) are DNA viruses belonging to the family of Herpesviridae. They occur globally. In industrialized countries the seroprevalence amounts to 50% in the second decade of life, in adults even up to 90% for HSV 1 and 10 to 15% for HSV 2. The transmission of Herpes Simplex Virus 1 occurs by contact with contaminated salivary or smear infection. Herpes Simplex Virus 2 is transmitted via contact with infected mucosal skin. Primary HSV 1 infections process inapparently in 90% of cases. 10% of infected persons suffer from inflammations of cornea and conjunctiva or show the characteristic herpes vesiculation at the lips. These pustular eruptions can spread on eczematous skin with life-threatening effects. Other complications are encephalitis or meningoencephalitis. 12% of primary HSV 2 infections are apparent with sudden abortion, vulvovaginitis or penis scrotum efflorescences. |
| Detection and diagnosis An important field of application for HSV serology - also during latency - is the detection of serotype-specific HSV IgG antibodies in order to identify potential HSV carriers who could infect susceptible individuals. In particular, the identification of HSV 2 serotype-specific antibodies in pregnant women, who present a high risk of transferring the virus to a newborn child, is recommended. The serological typing of an HSV infection is usually performed by identifying IgG antibodies directed against the viral surface glycoproteins G (gG) of HSV 1 (gG1) and HSV 2 (gG2). Due to the fact that these antibodies are only produced some weeks after a primary infection, the determination of serotype-specific antibodies can also assist in the differentiation between primary infection and reactivation |
Publications
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| BC105A protocol |
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