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Chikungunya Virus IgG ELISA Kit ESR148G

$334.00

Summary

  • Virion/Serion Diagnostic Kit for research use (RUO)
  • Chikungunya Virus IgG ELISA Kit
  • Suitable for IgG detection
  • Ready-to-use
  • 96 tests
Weight1 lbs
Dimensions9 × 5 × 2 in
target

Chikungunya Virus reactive IgG

species reactivity

Chikungunya virus

applications

ELISA

assay type

Indirect & quantitative

available sizes

96 tests

Available product – Chikungunya Virus IgG ELISA Kit ESR148G

kit
Assay type
Indirect ELISA
Research area
Infectious Disease
Sample type
Serum, plasma, whole blood
Notes
Pretreatment of samples with RF-Absorbent (Z200) is recommended for use with IgM ELISA kits to eliminate presence of sample rheumatoid factors and possible false negative results.
Components
Break apart microtiter test strips each with antigen coated single wells8 x 12 (96 Total)
Standard serum (ready-to-use)2 x 2 mL
Negative control serum (ready-to-use)2 mL
Anti-human-IgG-conjugate (ready-to-use)13 mL
Washing solution concentrate (sufficient for 1000ml)33.3 mL
Dilution buffer2 x 50 mL
Stopping solution15 mL
Substrate (ready-to-use)13 mL
Quality control certificate with standard curve and evaluation table1
Storage
Store at 2-8°C.
Associated products
Chikungunya Glycoprotein E2 Antigen (BA148R1)
Chikungunya Glycoprotein E1 Antigen (BA148R2)
Chikungunya Glycoprotein E1 (A226V) Antigen (BA148R3)
Chikungunya Virus Human IgG Assay Control (BC148G)
Chikungunya Virus Human IgM Assay Control (BC148M)
Chikungunya Virus IgG ELISA Kit (ESR148G)
Chikungunya Virus IgM ELISA Kit (ESR148M)
target relevance
Organism
Chikungunya Virus
Structure and strains
Chikungunya is an infection caused by the Chikungunya virus (CHIKV). The disease was first identified in 1952 in Tanzania and named based on the Kimakonde words for "to become contorted". Symptoms include fever and joint pain. These typically occur two to twelve days after exposure. Other symptoms may include headache, muscle pain, joint swelling, and a rash. Symptoms usually improve within a week; however, occasionally the joint pain may last for months or years. The risk of death is around 1 in 1,000. The very young, old, and those with other health problems are at risk of more severe disease.
Disease
The chikungunya virus is a member of the alphavirus genus. It is also classified as arbovirus due to vector-dependent transmission by mosquitos. The enveloped virus carries structural glycoproteins E1-E3 that are particular immunogenic. Within the viral capsid several non-structure proteins and a ss-(+)-RNA genome are embedded.

The virus is the causative agent of chikungunya fever that is characterized by fever, joint pain and joint swelling, rash, and unspecific flu-like symptoms. The symptoms usually appear within a period of one to two weeks but mainly appear during the first week post infection. The disease is characterized by a biphasic course with an initial stage with high virus load (5-7 days) and a convalescent stage without viremia. A chronic course of disease that goes along with severe joint pain might occur. In rare cases neurological disorders like Guillain-Barre syndrome and meningoencephalitis, also with lethal courses, were described.
Detection and diagnosis
The diagnosis is mainly based on direct pathogen detection or serological methods. Within the early phases virus detection by RT-PCR is the method of choice. After the onset of immune responses viremia will drop leading to reduced sensitivity of direct detection methods. Achieving this stage demonstration of specific antibodies should be used for diagnosis. Due to persistence of IgG and to lesser extent IgM antibody serology allows for retrospective evaluation.

Data

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
ESR148G protocol

Documents

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