Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | chicken |
isotype | IgY |
clonality | polyclonal |
concentration | 1 mg/mL |
applications | ICC/IF, IHC, WB |
reactivity | human, mouse, rat |
available sizes | 1 mg, 100 µg, 25 µg |
chicken anti-GFAP polyclonal antibody 6048
$100.00 – $2,600.00
Antibody summary
- Chicken polyclonal to GFAP
- Suitable for: WB, ICC/IF, IHC
- Reacts with: human, mouse, rat
- Isotype: IgY
- 100 µg, 25 µg, 1 mg
chicken anti-GFAP polyclonal antibody 6048
target relevance |
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Glial Fibrillary Acidic Protein (GFAP) is a crucial cell marker widely employed in neuroscience and neurobiology research. It is an intermediate filament protein primarily found in astrocytes, a type of glial cell in the central nervous system. GFAP serves as a reliable marker for identifying and characterizing astrocytes in various experimental models and tissues. Immunohistochemistry and immunofluorescence techniques using antibodies targeting GFAP enable researchers to visualize and quantify astrocytic populations, gaining insights into their distribution, morphology, and function in the brain. Moreover, GFAP antibodies are instrumental in studying astrocyte reactivity, a phenomenon occurring in response to brain injury or neurodegenerative diseases. As astrocytes play critical roles in neural development, neurotransmitter regulation, and maintenance of the blood-brain barrier, GFAP has proven indispensable in advancing our understanding of glial biology and its contribution to neurological disorders. Click for more on: cell markers and GFAP |
Protein names Glial fibrillary acidic protein (GFAP) |
Gene names GFAP,GFAP |
Protein family Intermediate filament family |
Mass 49880Da |
Function GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. |
Subellular location Cytoplasm Note=Associated with intermediate filaments. |
Tissues Expressed in cells lacking fibronectin. |
Structure Interacts with SYNM. ; [Isoform 2]: Interacts with PSEN1 (via N-terminus). |
Post-translational modification Phosphorylated by PKN1. |
Involvement in disease Alexander disease (ALXDRD) [MIM:203450]: A rare disorder of the central nervous system. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death within the first decade. Infants with Alexander disease develop a leukodystrophy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. Histologically, Alexander disease is characterized by Rosenthal fibers, homogeneous eosinophilic inclusions in astrocytes. Note=The disease is caused by variants affecting the gene represented in this entry. |
Target Relevance information above includes information from UniProt accession: P14136 |
The UniProt Consortium |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.There are 546 publications in our database for this antibody or clone. Here are the latest 5, for more click below.
pmid | title | authors | citation |
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36828035 | WWOX P47T partial loss-of-function mutation induces epilepsy, progressive neuroinflammation, and cerebellar degeneration in mice phenocopying human SCAR12 | Hussain T, Sanchez K, Crayton J, Saha D, Jeter C, Lu Y, Abba M, Seo R, Noebels JL, Fonken L, Aldaz CM. | Prog Neurobiol. 2023 Apr;223:102425. doi: 10.1016/j.pneurobio.2023.102425. Epub 2023 Feb 23. |
36640336 | Neuronal and astrocytic contributions to Huntington's disease dissected with zinc finger protein transcriptional repressors | Gangwani MR, Soto JS, Jami-Alahmadi Y, Tiwari S, Kawaguchi R, Wohlschlegel JA, Khakh BS. | Cell Rep. 2023 Jan 31;42(1):111953. doi: 10.1016/j.celrep.2022.111953. Epub 2023 Jan 7. |
36633130 | ASK1 inhibitor NQDI‑1 decreases oxidative stress and neuroapoptosis via the ASK1/p38 and JNK signaling pathway in early brain injury after subarachnoid hemorrhage in rats | Duan J, Yuan W, Jiang J, Wang J, Yan X, Liu F, Liu A. | Mol Med Rep. 2023 Feb;27(2):47. doi: 10.3892/mmr.2023.12934. Epub 2023 Jan 12. |
36614107 | Cerebral Folate Metabolism in Post-Mortem Alzheimer's Disease Tissues: A Small Cohort Study | Naz N, Naqvi SF, Hohn N, Whelan K, Littler P, Roncaroli F, Robinson AC, Miyan JA. | Int J Mol Sci. 2022 Dec 30;24(1):660. doi: 10.3390/ijms24010660. |
36593462 | Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function | Konstantinidis E, Portal B, Mothes T, Beretta C, Lindskog M, Erlandsson A. | J Neuroinflammation. 2023 Jan 3;20(1):3. doi: 10.1186/s12974-022-02687-5. |
Protocols
relevant to this product |
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Western blot IHC ICC |
Documents
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Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. |
122 reviews for chicken anti-GFAP polyclonal antibody 6048
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