Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with anti-desmoglein-3 monoclonal antibody using peroxidase-conjugate and DAB chromogen. Note membranous staining of tumor cells

rabbit anti-Desmoglein-3 monoclonal antibody (ZR128) 6159

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to Desmoglein-3
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Squamous cell carcinoma
Visualization: Membrane
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

available sizes

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SKU: 6159parent Category: antibody Tags: anatomy, Dermatopathology, Desmoglein-3

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-Desmoglein-3 monoclonal antibody ZR128 6159

antibody
Database link: human Q14574
Tested applications IHC
Recommended dilutions Concentrated 1:100
Application Notes Positive control: Squamous cell carcinoma
Immunogen Recombinant fragment (around aa 379-491) human DSG3 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Desmocollin-3 (Cadherin family member 3) (Desmocollin-4) (HT-CP)
Gene names DSC3,DSC3 CDHF3 DSC4
Mass 99969Da
Function FUNCTION: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Subellular location SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome.
Tissues TISSUE SPECIFICITY: Epidermis, buccal mucosa, esophagus and cervix.
Domain DOMAIN: Calcium may be bound by the cadherin-like repeats. {ECO:0000305}.; DOMAIN: Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000250}.
Involvement in disease DISEASE: Hypotrichosis and recurrent skin vesicles (HRSV) [MIM:613102]: A disorder characterized by hypotrichosis and the appearance of recurrent skin vesicle formation. Affected individuals show sparse and fragile hair on scalp, as well as absent eyebrows and eyelashes. Vesicles filled with thin, watery fluid are observed on the scalp and skin of most of the body. Mucosal vesicles are absent. {ECO:0000269\|PubMed:19765682}. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: Q14574
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with anti-desmoglein-3 monoclonal antibody using peroxidase-conjugate and DAB chromogen. Note membranous staining of tumor cells

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.