| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | mouse |
| isotype | IgG2a |
| clonality | monoclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Human von Willebrand Factor |
| available sizes | 200 µg |
mouse anti-von Willebrand Factor monoclonal antibody (VW92-3) 5389
$497.00
Antibody summary
- Mouse monoclonal to von Willebrand Factor
- Suitable for: WB,IHC
- Isotype: IgG2a
- 200 µg
mouse anti-von Willebrand Factor monoclonal antibody (VW92-3) 5389
| antibody |
|---|
| Tested applications WB,IHC,IHC |
| Recommended dilutions ELISA: 1-10ug/ml with vWF on the solid phase Western Blot: 5-10ug/ml; useful under non-reducing conditions. Immunohistochemistry: 5-10ug/ml on paraffin embedded and frozen tissue sections. |
| Immunogen Human plasma von Willebrand Factor. |
| Size and concentration 200µg and |
| Form lyophilized |
| Storage Instructions The stock solution (2. 0mg/ml) can be stored in aliquots at - 20°C for 1 year or can be stored at 4°C for 6 months after adding 0.1% sodium azide. Dilutions of stock solution should not |
| Storage buffer PBS, 1% BSA, pH 7.4, lyophilized. |
| Purity immunogen affinty purifcation |
| Clonality monoclonal |
| Isotype IgG2a |
| Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721 |
| Isotype control Mouse monocolonal IgG2a - Isotype Control |
| target relevance |
|---|
| Protein names von Willebrand factor (vWF) [Cleaved into: von Willebrand antigen 2 (von Willebrand antigen II)] |
| Gene names VWF,VWF F8VWF |
| Mass 309265Da |
| Function FUNCTION: Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. |
| Subellular location SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10961880}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10961880}. Note=Localized to storage granules. |
| Tissues TISSUE SPECIFICITY: Plasma. |
| Structure SUBUNIT: Multimeric. Interacts with F8. {ECO:0000269|PubMed:10961880, ECO:0000269|PubMed:9218428}. |
| Post-translational modification PTM: All cysteine residues are involved in intrachain or interchain disulfide bonds.; PTM: N- and O-glycosylated. {ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}. |
| Target Relevance information above includes information from UniProt accession : P04275 |
| The UniProt Consortium |
Data
| No results found |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
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Protocols
| relevant to this product |
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| Western blot IHC |
Documents
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