Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | mouse |
isotype | IgG1 |
clonality | monoclonal |
concentration | 1 mg/mL |
applications | ICC/IF, IHC, WB |
reactivity | modified proteins |
available sizes | 1 mg, 100 µg, 25 µg |
mouse anti-Ubiquitin monoclonal antibody (Ubi1) 1737
$100.00 – $2,600.00
Antibody summary
- Mouse monoclonal to Ubiquitin
- Suitable for: WB, ICC/IF, IHC
- Reacts with: all
- Isotype: IgG1
- 100 µg, 25 µg, 1 mg
mouse anti-Ubiquitin monoclonal antibody (Ubi1) 1737
antibody |
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Database link: Ubiquitin Sequence - MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG |
Tested applications WB,IHC,IHC,ICC/IF |
Recommended dilutions WB: 1:1000-1:2000 ICC/IF and IHC: 1:2000 |
Immunogen Purified bovine erythrocyte ubiquitin coupled to KLH with glutaraldehyde |
Size and concentration 25, 100, 1000µg and 1 mg/mL |
Form liquid |
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles. |
Storage buffer PBS, 50% glycerol, 0.04% NaN3 |
Purity affinity purified |
Clonality monoclonal |
Isotype IgG1 |
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721 |
Isotype control Mouse monocolonal IgG1 - Isotype Control |
target relevance |
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Ubiquitin plays a fundamental role in cell biology as a key regulator of protein degradation and cellular processes. More on: cell markers and ubiquitin |
Biotechnology Ubiquitin, a small protein found in nearly all eukaryotic cells, plays a fundamental role in regulating various cellular processes. Its primary function is to mark proteins for degradation through the ubiquitin-proteasome system, a highly controlled and selective process known as ubiquitination. When a protein is destined for degradation or clearance, multiple ubiquitin molecules are covalently attached to specific lysine residues on the target protein, forming a polyubiquitin chain. This ubiquitin chain acts as a signal, directing the tagged protein to the proteasome, a large multi-subunit protein complex responsible for protein degradation. Once delivered to the proteasome, the ubiquitinated protein is unfolded and processed, and its constituent amino acids are recycled for the synthesis of new proteins. Apart from its role in protein degradation, ubiquitin also participates in various non-proteolytic functions, such as DNA repair, endocytosis, and signal transduction, where monoubiquitination or other ubiquitin modifications can serve as regulatory signals. The precise and intricate control of ubiquitin-mediated processes ensures proper cellular homeostasis, protein turnover, and the maintenance of critical cellular functions. |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.There are 97 publications in our database for this antibody or clone. Here are the latest 5, for more click below.
pmid | title | authors | citation |
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36378690 | The autophagic protein p62 is a target of reactive aldehydes in human and murine cholestatic liver disease | Shearn CT, Anderson AL, Devereux MW, Orlicky DJ, Michel C, Petersen DR, Miller CG, Harpavat S, Schmidt EE, Sokol RJ. | PLoS One. 2022 Nov 15;17(11):e0276879. doi: 10.1371/journal.pone.0276879. eCollection 2022. |
36121476 | Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo | Lackie RE, de Miranda AS, Lim MP, Novikov V, Madrer N, Karunatilleke NC, Rutledge BS, Tullo S, Brickenden A, Maitland MER, Greenberg D, Gallino D, Luo W, Attaran A, Shlaifer I, Del Cid Pellitero E, Schild-Poulter C, Durcan TM, Fon EA, Duennwald M, Beraldo FH, Chakravarty MM, Bussey TJ, Saksida LM, Soreq H, Choy WY, Prado VF, Prado MAM. | Acta Neuropathol. 2022 Nov;144(5):881-910. doi: 10.1007/s00401-022-02491-8. Epub 2022 Sep 19. |
35388108 | Melatonin reduces the endoplasmic reticulum stress and polyubiquitinated protein accumulation induced by repeated anesthesia exposure in Caenorhabditis elegans | Shin HJ, Koo BW, Yoon J, Kim H, Do SH, Na HS. | Sci Rep. 2022 Apr 6;12(1):5783. doi: 10.1038/s41598-022-09853-y. |
34819832 | Suppressor of Cytokine Signaling 2 Regulates Retinal Pigment Epithelium Metabolism by Enhancing Autophagy | Liu XY, Lu R, Chen J, Wang J, Qian HM, Chen G, Wu RH, Chi ZL. | Front Neurosci. 2021 Nov 8;15:738022. doi: 10.3389/fnins.2021.738022. eCollection 2021. |
34646768 | OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties | Liu G, Guo W, Qin J, Lin Z. | Front Oncol. 2021 Sep 27;11:711735. doi: 10.3389/fonc.2021.711735. eCollection 2021. |
Protocols
relevant to this product |
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Western blot IHC ICC |
Documents
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Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. |
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