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mouse anti-Measles Phosphoprotein monoclonal antibody (9H4) 3804

$520.00

Antibody summary

  • Mouse monoclonal to Measles Phosphoprotein
  • Suitable for: WB,ICC,ELISA
  • Isotype: IgG1
  • 100 µg
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SKU: 3804parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

mouse

isotype

IgG1

clonality

monoclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

Measles Phosphoprotein

available sizes

100 µg

antibody
Tested applications
WB,ICC/IF,ELISA
Recommended dilutions
ELISA: use at 0.1-1.0ug/ml

Immunoblotting:

User should use at 1-5ug/ml. A band of ~70kDa is detected

Immunocytochemistry: use at 2- 10ug/ml on virus-infected cells.

These are recommended concentrations.

End user should determine optimal concentrations for the
Immunogen
Recombinant Measles virus phosphoprotein.
Size and concentration
100µg and
Form
lyophilized
Storage Instructions
This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.
Storage buffer
Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose
Purity
protein affinty purification
Clonality
monoclonal
Isotype
IgG1
Compatible secondaries
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486
goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706
goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control
Mouse monocolonal IgG1 - Isotype Control
target relevance
Protein names
Phosphoprotein (Protein P)
Gene names
P/V,P/V
Protein family
Morbillivirus P protein family
Mass
54101Da
Function
FUNCTION: Essential cofactor of the RNA polymerase L that plays a central role in the transcription and replication by forming the polymerase complex with RNA polymerase L and recruiting L to the genomic N-RNA template for RNA synthesis (By similarity). Plays also a central role in the encapsidation of nascent RNA chains by forming the encapsidation complex with the nucleocapsid protein N (N-P complex). Acts as a chaperone for newly synthesized free N protein, so-called N0, allowing encapsidation of nascent RNA chains during replication (By similarity). The nucleoprotein protein N prevents excessive phosphorylation of P, which leads to down-regulation of viral transcription/ replication. Participates, together with N, in the formation of viral factories (viroplasms), which are large inclusions in the host cytoplasm where replication takes place (By similarity). {ECO:0000250|UniProtKB:P06162, ECO:0000250|UniProtKB:Q77M42}.
Structure
SUBUNIT: Homotetramer. Interacts (via multimerization domain) with polymerase L; this interaction forms the polymerase L-P complex (By similarity). Interacts (via N-terminus) with N0 (via Ncore); this interaction allows P to chaperon N0 to avoid N polymerization before encapsidation. Interacts (via C-terminus) with N-RNA template; this interaction positions the polymerase on the template for both transcription and replication (By similarity). {ECO:0000250|UniProtKB:P06162, ECO:0000250|UniProtKB:Q77M42}.
Post-translational modification
PTM: Phosphorylation on serines by host CK2 is necessary for the formation of viral factories. {ECO:0000250|UniProtKB:Q77M42}.
Target Relevance information above includes information from UniProt accession : P35974
The UniProt Consortium

Data

No results found

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

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