Immunohistochemistry (IHC) : Human Hodgkin’s lymphoma stained with anti-EBV-LMP antibody using peroxidase-conjugate and DAB chromogen. Note intense cytoplasmic staining of Reed-Sternberg cells.

mouse anti-EBV-LMP monoclonal antibody (CS1-4) 6166

$160.00 – $528.00

Antibody summary

Mouse monoclonal to EBV-LMP
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG1
Control: EBV positive cells
Visualization: Cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6166parent Category: antibody Tags: anatomy, EBV-LMP, Infectious Markers

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

mouse anti-EBV-LMP monoclonal antibody CS1-4 6166

antibody

Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Applicaiton Notes Positive control: EBV positive cells
Immunogen Recombinant fusion protein containing the sequence of bacterial beta-galactosidase and the carboxyl half of EBV-encoded LMP
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG1
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monoclonal IgG1 - Isotype Control

target relevance
Structure The Epstein Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. Epstein-Barr virus (EBV) is the first identified oncogenic virus, which establishes permanent infection in humans. EBV causes infectious mononucleosis and is also tightly linked to many malignant diseases. Various vaccine formulations underwent testing in different animals or in humans. However, none of them was able to prevent EBV infection and no vaccine has been approved to date. The virus causes infectious mononucleosis ("mono" or "glandular fever"). It is also associated with various non-malignant, premalignant, and malignant Epstein Barr virus-associated lymphoproliferative diseases such as Burkitt lymphoma, hemophagocytic lymphohistiocytosis, and Hodgkin's lymphoma; non-lymphoid malignancies such as gastric cancer and nasopharyngeal carcinoma; and conditions associated with human immunodeficiency virus such as hairy leukoplakia and central nervous system lymphomas. The virus is also associated with the childhood disorders of Alice in Wonderland syndrome and acute cerebellar ataxia and, by some evidence, higher risks of developing certain autoimmune diseases, especially dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome. About 200,000 cancer cases globally per year are thought to be attributable to EBV. In 2022, a large study (population of 10 million over 20 years) suggested EBV as the leading cause of multiple sclerosis, with a recent EBV infection causing a 32-fold increase in the risk of developing multiple sclerosis.
Biotechnology IgG antibodies directed against early antigen (EA) and/or IgM antibodies against virus capsid antigens (VCA) in combination with negative EBNA1 IgG activity serve as evidence of acute primary infections. High IgG antibody activities against EBNA1 exclude acute primary infections. IgG antibodies directed against VCA can usually be detected life-long and serve as confirmation of contact with the pathogen. In reactivations, high IgG antibody activities directed against VCA and EA can frequently be found.
Involvement in disease The Epstein-Barr Virus is a worldwide distributed human pathogenic DNA virus of the family Herpesviridae. Seroprevalence in adults is high (90-95%). In adolescents and younger adults, infection with EBV frequently leads to the clinical manifestation of infectious mononucleosis. In primary EBV infections, cells of the salivary gland are infected first. This disease stage is accompanied by mild flu-like symptoms. As soon as the virus infects B cells in the adjacent lymphoid tissue and spreads throughout the body, the clinical picture of infectious mononucleosis or glandular fever occurs. This disease is usually characterized by high fever, splenomegalia, lymphadenitis, and thrombocytopenia. Furthermore, EBV infections are associated with nasopharyngeal carcinoma and Burkitt's lymphoma in some regions.

Data

Human Hodgkin's lymphoma stained with anti-EBV-LMP antibody using peroxidase-conjugate and DAB chromogen. Note intense cytoplasmic staining of Reed-Sternberg cells.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.