| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | mouse |
| isotype | IgG2/ κ + IgG1 |
| clonality | monoclonal |
| concentration | concentrate, predilute |
| applications | IHC |
| reactivity | human |
| available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
mouse anti-Cytomegalovirus monoclonal antibody 8B1.2&1G5.2&2D4.2 6126
$160.00 – $528.00
Antibody summary
- Mouse monoclonal to Cytomegalovirus (CMV)
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG2/ κ + IgG1
- Control: CMV infected tissue
- Visualization: Nuclear
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
mouse anti-Cytomegalovirus monoclonal antibody 8B1.2&1G5.2&2D4.2 6126
| target relevance |
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| Structure Cytomegalovirus (CMV) is a genus of viruses in the order Herpesvirales, in the family Herpesviridae, in the subfamily Betaherpesvirinae. Humans and other primates serve as natural hosts. The 11 species in this genus include human betaherpesvirus 5 (HCMV, human cytomegalovirus, HHV-5), which is the species that infects humans. Diseases associated with HHV-5 include mononucleosis and pneumonia, and congenital CMV in infants can lead to deafness and ambulatory problems. In the medical literature, most mentions of CMV without further specification refer implicitly to human CMV. Human CMV is the most studied of all cytomegaloviruses. |
| Biotechnology The diagnosis of CMV infections is performed on the basis of clinical symptoms and medical examinations. For serological diagnosis immunoglobulin specific IgM and IgG ELISA and, when necessary, tests for avidity determination are recommended. |
| Involvement in disease Cytomegalovirus (CMV) is a human pathogenic DNA virus belonging to the herpes virus group. Primary infection may result from contact with saliva, genital secretions, urine and breast milk of infected persons, as well as from transfusions or transplantations. Primary infections usually remain asymptomatic. Clinical manifestations vary considerably depending on age and immunocompetence ranging from localized infections to generalized diseases. Significant clinical diseases or death may follow infection of immunocompromized individuals. Reactivation in immunocompetent adults is usually asymptomatic but accompanied by virus secretion. In immunocompromized patients reactivation of CMV infections may result in clinically severe diseases. CMV infection is a major cause of complications in iatrogenic immunsuppression after organ transplantation and in HIV infected persons. CMV is the most important causative agent of congenital and postnatal infections. Primary infections as well as reactivations during pregnancy may result in fetopathy. The risk of fetal damage is higher in cases of primary infections than during reactivations. |
Data
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| Human CMV infected lung stained with anti-CMV antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of infected alveolar cells. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
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Protocols
| relevant to this product |
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| IHC |
Documents
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| Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. | |||
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