Human Cytomegalovirus IgM Lateral flow dipstick kit 5573

$487.00

Summary

Mikrogen diagnostik lateral flow device (dipstick) for research use (RUO)
Human Cytomegalovirus IgM Lateral flow dipstick kit 5573
Suitable for IgM detection
Ready-to-use
20 tests

SKU: 5573 Category: Mikrogen kits Tags: Cytomegalovirus, IgM, Lateral Flow Dipsticks

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Human Cytomegalovirus IgM
species reactivity	Human Cytomegalovirus
applications	Lateral flow (dipstick)
assay type	Indirect & qualitative
available sizes	2x 20 test kits

Human Cytomegalovirus IgM Lateral flow dipstick kit 5573

Assay type
Sandwich assay, lateral flow (dipstick)

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instructions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 kits of [2 Vials x 10 Each]
Anti-Human IgM Conjugate	500 µL
Positive Control	140 µL
Negative Control	140 µL

Storage
Store at 2-8°C.

Additional information

Mikrogen recomLine Helicobacter 2.0 tests are serological, qualitative in vitro line immunoassays for the detection of antibodies against ten selected Helicobacter pylori antigens. The detection of antibodies against the two most important virulence factors CagA and VacA are of high diagnostic importance. These two virulence factors significantly increase the risk for premalignant changes, gastric carcinoma, MALT lymphoma, and ulcers. Humoral immune responses against the GroEL, HtrA, NapA, HP231, and CtkA biomarkers are associated with more severe disease progression.

Advantages

Sensitivity: > 99% IgG positive results of gold standard positive patients.
Specificity: 100% IgG and IgA negative results of gold standard negative patients.
Excellent correlation with the gold standard of Helicobacter pylori diagnostics - culture and histology.
Reliable results at all times, even with low colonization density.
Identification of highly virulent Helicobacter pylori type I infections using CagA.
Detection of antibodies against ten relevant biomarkers and virulence factors associated with more severe disease progression.
Simple and clear interpretation through easy-to-read banding.
Partial and full automation, software-based evaluation (recomScan), and integration with laboratory information system possible.
Highest sensitivity and specificity through the use of recombinant antigens:

target relevance

human antibody anti-Cytomegalovirus (CMV)

Cytomegalovirus (CMV)

Description
Virus that causes cytomegalovirus infection and congenital CMV disease

Structure
Cytomegalovirus (CMV), also known as Human herpesvirus 5 (HHV-5), is an enveloped, double-stranded DNA virus belonging to the genus Cytomegalovirus within the family Herpesviridae. The virus possesses an icosahedral capsid surrounded by a protein tegument and a lipid envelope containing multiple glycoproteins involved in host cell entry. CMV has one of the largest genomes among human viruses and is capable of infecting a wide variety of cell types including epithelial cells, endothelial cells, fibroblasts, monocytes, and leukocytes. Following primary infection, CMV establishes lifelong latency, primarily within cells of the myeloid lineage, and may periodically reactivate, particularly in immunocompromised individuals. CMV is widely distributed throughout the world, and a large proportion of adults show evidence of prior infection.

Diagnosis
The diagnosis of cytomegalovirus infection is performed through serological, molecular, and virological methods. Detection of CMV-specific IgM and IgG antibodies by ELISA or other immunoassays is commonly used to determine recent or past infection. Molecular methods such as quantitative polymerase chain reaction (PCR) are highly sensitive and are widely used to detect and monitor CMV DNA in blood, urine, saliva, cerebrospinal fluid, and other clinical specimens. Antigenemia assays and viral culture may also be employed in selected clinical settings. In pregnant women and immunocompromised patients, laboratory testing is particularly important for assessing active infection, viral load, and risk of disease progression.

Symptoms
Most cytomegalovirus infections in healthy individuals are asymptomatic or cause mild, self-limiting illness resembling infectious mononucleosis, characterized by fever, fatigue, malaise, sore throat, lymphadenopathy, and muscle aches. Following primary infection, the virus remains latent and may reactivate later in life. In immunocompromised individuals, including transplant recipients, cancer patients, and people with advanced HIV infection, CMV can cause severe disease involving the lungs, liver, gastrointestinal tract, retina, and central nervous system. Congenital CMV infection is a major cause of birth defects and may result in hearing loss, vision impairment, developmental delays, microcephaly, seizures, and other neurological complications. CMV remains one of the most significant opportunistic viral pathogens worldwide.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Human Cytomegalovirus IgM Lateral Flow Dipstick Kit 5573?

The kit is suitable for testing serum, plasma, and whole blood samples for the presence of Human Cytomegalovirus IgM antibodies.

How should the Human Cytomegalovirus IgM Lateral Flow Dipstick Kit 5573 be stored to maintain its stability?

The kit should be stored at 2-8°C to ensure stability and optimal performance of its components.

What is the assay format and detection principle used in this Human Cytomegalovirus IgM test kit?

This product uses a sandwich assay format with a lateral flow (dipstick) device for indirect and qualitative detection of Human Cytomegalovirus IgM antibodies.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU). 5573 protocol