| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| host | mouse |
| isotype | IgG1 |
| clonality | monoclonal |
| concentration | 1 mg/mL |
| applications | ICC/IF, WB |
| reactivity | Cytokine Receptor-like Factor 2 |
| available sizes | 100 µg |
mouse anti-Cytokine Receptor-Like Factor 2 monoclonal antibody (8H8) 3284
$520.00
Antibody summary
- Mouse monoclonal to Cytokine Receptor-Like Factor 2
- Suitable for: WB,IHC,ELISA
- Isotype: IgG1
- 100 µg
mouse anti-Cytokine Receptor-Like Factor 2 monoclonal antibody (8H8) 3284
| antibody |
|---|
| Tested applications WB,IHC,IHC,ELISA |
| Recommended dilutions ELISA: use at 0.05-0.10ug/ml. Immunoblotting: use at 0.5-1ug/ml. A band of ~42kDa is detected. Immunohistochemistry: Formalin-fixed, paraffin-embedded tissue. Use at 1- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations fo |
| Immunogen Recombinant human TSLPR- Fc fusion protein. Accession no. Q9HC73. |
| Size and concentration 100µg and |
| Form lyophilized |
| Storage Instructions This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles. |
| Storage buffer Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose |
| Purity protein affinty purification |
| Clonality monoclonal |
| Isotype IgG1 |
| Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721 |
| Isotype control Mouse monocolonal IgG1 - Isotype Control |
| target relevance |
|---|
| Protein names Cytokine receptor-like factor 2 (Cytokine receptor-like 2) (IL-XR) (Thymic stromal lymphopoietin protein receptor) (TSLP receptor) |
| Gene names CRLF2,CRLF2 CRL2 ILXR TSLPR |
| Protein family Type I cytokine receptor family, Type 5 subfamily |
| Mass 42013Da |
| Function FUNCTION: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {ECO:0000250, ECO:0000269|PubMed:11418668}. |
| Subellular location SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}. |
| Tissues TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells. |
| Structure SUBUNIT: Heterodimer of CRLF2 and IL7R. |
| Domain TOPO_DOM 2 |
| Target Relevance information above includes information from UniProt accession : Q9HC73 |
| The UniProt Consortium |
Data
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| Immunohistochemistry: Formalin-fixed, paraffin-embedded tissue. Use at 110ug/ml. Staining of human thymus with #3284. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
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Protocols
| relevant to this product |
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| Western blot IHC |
Documents
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