IHC mouse anti collagen v alpha 1 chain vr domain monoclonal antibody 6a7 5507

mouse anti-Collagen V α-1 Chain (VR domain) monoclonal antibody (6A7) 5507

$520.00

Antibody summary

Mouse monoclonal to Collagen V α-1 Chain (VR domain)
Suitable for: WB,IHC
Isotype: IgG1
100 µg

SKU: 5507parent Category: antibody Tag: antibodies

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	1 mg/mL
applications	ICC/IF, WB
reactivity	Collagen Vα-1 Chain N-propeptide-VR domain
available sizes	100 µg

mouse anti-Collagen V α-1 Chain (VR domain) monoclonal antibody (6A7) 5507

antibody

Tested applications WB,IHC,IHC
Recommended dilutions Immunoblotting: use at 1-5ug/mL. Immunohistochemistry: Formalin-fixed, paraffin-embedded tissue, heat-induced antigen retrieval. Use at 1-10ug/mL. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Immunogen Recombinant human collagen V alpha-1 chain.
Size and concentration 100µg and
Form lyophilized
Storage Instructions This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.
Storage buffer Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose
Purity protein affinty purification
Clonality monoclonal
Isotype IgG1
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monocolonal IgG1 - Isotype Control

target relevance
Protein names Collagen alpha-1(V) chain
Gene names COL5A1,COL5A1
Protein family Fibrillar collagen family
Mass 183560Da
Function Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
Subellular location Secreted, extracellular space, extracellular matrix .
Structure Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
Post-translational modification Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.; Sulfated on 40% of tyrosines.
Involvement in disease DISEASE: Ehlers-Danlos syndrome, classic type, 1 (EDSCL1) [MIM:130000]: A form of Ehlers-Danlos syndrome, a group of connective tissue disorders characterized by skin hyperextensibility, articular hypermobility, and tissue fragility. The main features of classic Ehlers-Danlos syndrome are joint hypermobility and dislocation, and fragile, bruisable skin. EDSCL1 inheritance is autosomal dominant. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Fibromuscular dysplasia, multifocal (FMDMF) [MIM:619329]: An autosomal dominant vascular disorder with incomplete penetrance, characterized by fibrous tissue and webs developing in the artery wall and leading to multiple arterial stenoses. Patients with multifocal fibromuscular dysplasia can develop arterial tortuosity, macroaneurysms, and dissections. Arterial rupture may occur. Note=The disease is caused by variants affecting the gene represented in this entry.
Target Relevance information above includes information from UniProt accession: P20908
The UniProt Consortium