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mouse anti-CA-125 monoclonal antibody (306) 7857

$295.00

Antibody summary

  • Mouse monoclonal to CA-125
  • Suitable for: WB,ELISA
  • Isotype: IgG1
  • 100 µg
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SKU: 7857parent Category: Tags: , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
host

mouse

isotype

IgG1

clonality

monoclonal

concentration

1 mg/mL

applications

ICC/IF, WB

reactivity

CA-125/MUC16

available sizes

100 µg

antibody
Tested applications
WB,ELISA
Recommended dilutions
These antibodies may be used in ELISA and Western blotting to detect CA-125.

Positive control: OVCAR3 ovarian adenocarcinoma cells.
Immunogen
CA-125 purified from ovarian carcinoma cells.
Size and concentration
100µg and lot specific
Form
liquid
Storage Instructions
These antibodies are stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Storage buffer
10mM Tris buffer, pH 7.5, 0.15M NaCL, 0.05% NaN
Purity
ion exchange
Clonality
monoclonal
Isotype
IgG1
Compatible secondaries
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486
goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854
goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706
goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716
goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control
Mouse monocolonal IgG1 - Isotype Control
target relevance
Protein names
Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)
Gene names
MUC16,MUC16 CA125
Mass
1519175Da
Function
FUNCTION: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. {ECO:0000250}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.
Tissues
TISSUE SPECIFICITY: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas. {ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296, ECO:0000269|PubMed:16384952}.
Structure
SUBUNIT: Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.
Post-translational modification
PTM: Heavily O-glycosylated; expresses both type 1 and type 2 core glycans. {ECO:0000269|PubMed:12734200}.; PTM: Heavily N-glycosylated; expresses primarily high mannose and complex bisecting type N-linked glycans. {ECO:0000269|PubMed:12734200}.; PTM: May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. {ECO:0000269|PubMed:9276028}.; PTM: May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts.
Domain
TOPO_DOM 1
Target Relevance information above includes information from UniProt accession : Q8WXI7
The UniProt Consortium

Data

No results found

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

pmidtitleauthorscitation

Protocols

relevant to this product
Western blot
IHC
ICC

Documents

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