mouse anti-8-hydroxy Guanosine DNA/RNA damage monoclonal antibody (15A3) 1102

$220.00 – $450.00

Antibody summary

Mouse monoclonal to 8-hydroxy-guanosine
Suitable for: ELISA, IHC, ICC, WB
Reacts with: All
Isotype: IgG2b
100 µg, 500 µg

SKU: 1102parent Categories: antibody, oxidative stress Tags: 8-hydroxy-guanosine, DNA/RNA damage

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG2b
clonality	monoclonal
concentration	1 mg/mL
applications	ELISA, ICC, IHC, WB
reactivity	all, human
available sizes	100 µg, 500 µg

mouse anti-8-hydroxy Guanosine DNA/RNA damage monoclonal antibody (15A3) 1102

antibody

Tested applications ELISA, ICC, IHC, WB
Recommended dilutions Dilute in PBS or medium that is identical to that used in the assay system. Optimal concentrations must be derived for specific applications.
Immunogen 8-hydroxy-guanosine
Size and concentration 100, 500µg and 1 mg/mL
Form liquid
Storage Instructions Store antibody at -20C to -80C. Avoid multiple freeze-thaw cycles.
Storage buffer PBS, pH 7.4
Purity protein G affinity purified
Clonality monoclonal
Isotype IgG2b
Compatible secondaries goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 5486 goat anti-mouse IgG, H&L chain specific, biotin conjugated, Conjugate polyclonal antibody 2685 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody 7854 goat anti-mouse IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1706 goat anti-mouse IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1716 goat anti-mouse IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1721
Isotype control Mouse monoclonal IgG2b - Isotype Control

target relevance
Protein names 8-hydroxy-guanosine modified proteins
Gene names 8hydroxyG,8-hydroxy-2'-deoxyguanosine, 8-hydroxydeoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-7-hydrodeoxyguanosine, 8-OHdG, 2'-deoxy-8-oxoguanosine, 8-oxo-2'-deoxyguanine
Function Anti-8-hydroxyG, a mouse monoclonal antibody targeting oxidative damage in RNA, DNA, GTP and other nucleotide precursors and degradation products
Pathway Oxidative stress
Involvement in disease 8-Hydroxyguanosine (8-OHG) is a modified nucleoside that results from the oxidative damage to guanine, one of the four primary nucleobases in RNA. This oxidative modification is often used as a biomarker for oxidative stress and cellular damage, particularly in studies related to aging, cancer, and neurodegenerative diseases. 8-OHG formation occurs when reactive oxygen species (ROS) interact with guanine, leading to a hydroxylated form that can be incorporated into RNA. Its presence in biological systems is significant because it can lead to mutations during RNA synthesis, potentially altering protein expression and function. Elevated levels of 8-OHG are often detected in conditions where oxidative stress plays a pivotal role, making it a crucial marker for understanding the molecular mechanisms underlying various diseases and the aging process.

Data

No results found

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.