Human Yersinia IgA IgM Lateral flow dipstick kit 4673

$487.00

Summary

Mikrogen diagnostik lateral flow device (dipstick) for research use (RUO)
Human Yersinia IgA IgM Lateral flow dipstick kit 4673
Suitable for IgA/M detection
Ready-to-use
20 tests

SKU: 4673 Category: Mikrogen kits Tags: Lateral Flow Dipsticks, Yersinia

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Human Yersinia IgA (IgM)
species reactivity	Yersinia enterocolitica, Yersinia pseudotuberculosis
applications	Lateral flow (dipstick)
assay type	Indirect & qualitative
available sizes	20 test kits

Human Yersinia IgA IgM Lateral flow dipstick kit 4673

Assay type
Sandwich assay, lateral flow (dipstick)

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instructions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 kits of [2 Vials x 10 Each]
Anti-Human IgM Conjugate	500 µL
Positive Control	140 µL
Negative Control	140 µL

Storage
Store at 2-8°C.

Additional information
Mikrogen recomLine Yersinia Assays

For the Mikrogen recomLine Yersinia assays, the plasmid-encoded virulence proteins (Yersinia Outer Proteins) localized at the cell surface and adhesins for serological species differentiation between Y. enterocolitica and Y. pseudotuberculosis are produced recombinantly. These proteins are expressed only by human pathogenic Yersinia strains.

The recomLine Yersinia tests allow the detection of long-standing Yersinia infections and are thus ideally suited to identify Yersinia-induced immunopathological complications and chronic yersinioses. The detection of IgG and IgA antibodies can be an important aid in suspected Yersinia-induced arthritis.

Advantages

Detection of all human pathogenic Yersinia by means of Yersinia Outer Proteins (YOPs).
Differentiation between Y. enterocolitica and Y. pseudotuberculosis infection serologically possible by using new species-specific Yersinia antigens (PsaA, MyfA).
No cross-reactions to Brucella and other pathogens, and no interference by LPS.
Separate detection of IgG, IgA, and IgM antibodies - antibody class control on the test strip - helpful in case of suspected Yersinia-induced arthritis.
Partial and full automation, software-based evaluation (recomScan), and connection to the laboratory information system possible.
Highest sensitivity and specificity by using different, recombinant Yersinia antigens.

Bands

Antigen	Description
YOP M	Yersinia outer protein
V-AG	Yersinia virulence factor
PsaA	Adhesin (specific for Y. pseudotuberculosis)
YOP D	Yersinia outer protein
MyfA	Adhesin (specific for Y. enterocolitica)
YOP E	Yersinia outer protein

target relevance

human antibody anti-Yersinia

Yersinia

Description
Bacterial genus that causes yersiniosis, plague, and other zoonotic infections

Structure
Yersinia is a genus of Gram-negative, facultatively anaerobic coccobacilli belonging to the family Yersiniaceae. Members of the genus are widely distributed in nature and can infect a variety of mammalian hosts. The most clinically important species include Yersinia enterocolitica, Yersinia pseudotuberculosis, and Yersinia pestis. Y. enterocolitica and Y. pseudotuberculosis are primarily enteric pathogens that cause gastrointestinal disease, while Y. pestis is the causative agent of plague. Yersinia species possess numerous virulence factors, including adhesins, invasins, secretion systems, and plasmid-encoded proteins that enable invasion of host tissues and evasion of immune responses. The bacteria can survive and replicate within host cells and are capable of causing both localized and systemic infections.

Diagnosis
The diagnosis of Yersinia infection is performed through microbiological, molecular, and serological methods. Isolation of the organism from stool, blood, lymph node aspirates, or other clinical specimens remains the definitive diagnostic method. Selective culture techniques may be required, particularly for Yersinia enterocolitica. Polymerase chain reaction (PCR) assays provide rapid and sensitive detection of Yersinia DNA and are increasingly used in clinical laboratories. Serological tests, including ELISA-based assays, may be used to detect antibodies against Yersinia antigens and can be particularly useful in cases of post-infectious complications or epidemiological investigations. For plague caused by Yersinia pestis, rapid diagnosis is essential to enable prompt treatment and public health intervention.

Symptoms
Clinical manifestations of Yersinia infection vary depending on the infecting species. Yersinia enterocolitica and Yersinia pseudotuberculosis commonly cause yersiniosis, characterized by fever, abdominal pain, diarrhea, nausea, and vomiting. In older children and adults, infection may mimic acute appendicitis due to mesenteric lymphadenitis. Reactive arthritis and erythema nodosum can occur as post-infectious complications. Yersinia pestis causes plague, which may present as bubonic plague with painful swollen lymph nodes (buboes), septicemic plague with bloodstream infection, or pneumonic plague involving severe respiratory disease. Without prompt treatment, systemic Yersinia infections can progress to severe sepsis, organ failure, and death.

Data

FAQ & Publications

Frequently Asked Questions

What sample types are compatible with the Human Yersinia IgA IgM Lateral Flow Dipstick Kit 4673?

The kit is suitable for testing serum, plasma, and whole blood samples.

How should the Human Yersinia IgA IgM Lateral Flow Dipstick Kit 4673 be stored to maintain its stability?

The kit should be stored at a temperature between 2 and 8°C to ensure optimal stability and performance.

Which Yersinia species can be detected using this lateral flow dipstick kit, and how does it differentiate between them?

This kit detects antibodies against human pathogenic Yersinia species, specifically Yersinia enterocolitica and Yersinia pseudotuberculosis. It differentiates between these species serologically by using species-specific adhesins PsaA for Y. pseudotuberculosis and MyfA for Y. enterocolitica.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU). 4673 protocol