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Human Toxoplasma gondii IgM/IgA Lateral flow dipstick kit 5973

$487.00

Summary

  • Mikrogen diagnostik lateral flow device (dipstick) for research use (RUO)
  • Human Toxoplasma gondii IgM/IgA Lateral flow dipstick kit 5973
  • Suitable for IgM/A detection
  • Ready-to-use
  • 20 tests
Weight1 lbs
Dimensions9 × 5 × 2 in
target

Human Toxoplasma gondii IgM (IgA)

species reactivity

Human Toxoplasma gondii

applications

Lateral flow (dipstick)

assay type

Indirect & qualitative

available sizes

2x 20 test kits

Human Toxoplasma gondii IgM/IgA Lateral flow dipstick kit 5973

kit
Assay type
Sandwich assay, lateral flow (dipstick)
Research area
Infectious Disease
Sample type
Serum, plasma, whole blood
Components
10X Wash Buffer100 mL
TMB Substrate40 mL
Milk Powder5 g
Instructions for Use1 Each
Evaluation Form1 Each
Test Strips2 kits of [2 Vials x 10 Each]
Anti-Human IgA Conjugate500 μL
Positive Control140 μL
Negative Control140 μL
Storage
Store at 2-8°C.
Additional information
Mikrogen recomLine Toxoplasma Test

The Mikrogen recomLine Toxoplasma tests are serological, qualitative in vitro line immunoassays, which optimally combine the high requirements for the special diagnostics of toxoplasmosis, including during pregnancy, by using IgG and IgM specific recombinant antigens as well as 4 different avidity antigens to define the infection phases.

Advantages
  • Simple and meaningful avidity determination possible.
  • Band pattern and avidity determination allow conclusions to be drawn about infection status.
  • Precise information about the time of infection.
  • Separate detection of IgG, IgM, and IgA antibodies.
  • Easy and clear interpretation, featuring easy-to-read banding patterns.
  • No automation required, making it particularly suitable for small laboratories with low sample throughput capacity.
  • Partial and full automation, software-based evaluation (recomScan), and integration with the laboratory information system are possible.
  • Highest sensitivity and specificity due to the use of different, recombinant antigens.
Bands
AntigenOrigin
ROP1cTachyzoite and bradyzoite antigens
MIC3Tachyzoite antigens
GRA7Tachyzoite and bradyzoite antigens
GRA8Tachyzoite and bradyzoite antigens
p30Tachyzoite antigens
MAG1Tachyzoite antigens
GRA1Tachyzoite and bradyzoite antigens
rSAG1Tachyzoite antigens
target relevance
Organism
Toxoplasma gondii
Structure and strains
Toxoplasma gondii is a parasitic protozoan (specifically an apicomplexan) that causes toxoplasmosis. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals,: 1 but felids are the only known definitive hosts in which the parasite may undergo sexual reproduction.
Disease
Toxoplasma gondii is an eucaryotic protozoa of the sporozoa group. The obligatory intracellular parasite is distributed worldwide.

Following oral uptake of the parasite, e. g. with contaminated food, the organism penetrates the gut and enters the reticuloendothelial system. Due to the following hematogenous dissemination, Toxoplasma gondii is able to infect many different organs and tissues. Approximately 50% of infections with Toxoplasma gondii proceed subclinically. The remainder demonstrate only unspecific symptoms such as low fever, exhaustion, headache as well as muscle and joint pain after an incubation period of one to three weeks. A minority of patients suffer from high fever up to 39°C and swelling of lymph nodes. In 1% of infected children and young adults complications such as myocarditis, meningitis or pneumonia are reported. After recovery, Toxoplasma gondii persists in infected tissues by forming cysts.
Detection and diagnosis
The diagnosis of toxoplasmosis is based on clinical findings and serological investigations. ELISA tests are recommended for the demonstration of IgG and IgM antibodies. Screening for Toxoplasma infections during pregnancy is of significant importance in prenatal care. The transmission of Toxoplasma gondii via the transplacental route has been observed in all stages of pregnancy, although the risk of a prenatal transmission as well as the outcome of infection depends on the stage of pregnancy. The risk of an infection of the unborn child via transplacental transmission is limited to seronegative women who acquire a primary infection during pregnancy. IgM antibodies directed against Toxoplasma gondii can persist for months after infection. Therefore, the determination of the IgG antibody avidity allows for differentiation of primary from past infections.

Publications

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Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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