Skip to content

goat anti-MAP2 polyclonal antibody 8718


Antibody summary

  • Goat polyclonal to MAP2
  • Suitable for: WB, ICC/IF
  • Reacts with: human, mouse, rat
  • Isotype: IgG
  • 100 µg, 25 µg, 1 mg
SKU: 8718parent Categories: , Tags: ,
Weight1 lbs
Dimensions9 × 5 × 2 in







1 mg/mL



available sizes

1 mg, 100 µg, 25 µg

goat anti-MAP2 polyclonal antibody 8718

Database link:
human P11137
mouse P20357
rat P15146
Tested applications
Recommended dilutions
WB: 1:2000 IF/ICC and IHC: 1:1000-1:2000
Recombinant human projection domain sequences, amino acids 377-1505, EnCor products Prot-r-MAP2-P1, Prot-r-MAP2-P2 and Prot-r-MAP2-P3.
Size and concentration
25, 100, 1000µg and 1 mg/mL
Storage Instructions
2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Storage buffer
PBS, 50% glycerol, 0.04% NaN3
affinity purified
Compatible secondaries
donkey anti-goat IgG, H&L chain specific, peroxidase conjugated polyclonal antibody 1689
donkey anti-goat IgG, H&L chain specific, biotin conjugated polyclonal antibody 1699
donkey anti-goat IgG, H&L chain specific, FITC conjugated polyclonal antibody 1704
donkey anti-goat IgG, H&L chain specific, peroxidase conjugated polyclonal antibody, crossabsorbed 1709
donkey anti-goat IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1705
Isotype control
Goat polyclonal - Isotype Control
target relevance
As a key component of the cytoskeleton in neurons, MAP2 plays a critical role in regulating microtubule dynamics and stabilizing neuronal processes such as dendrites and axons. Its abundant presence in these structures makes it an essential factor in establishing and maintaining the intricate neuronal morphology required for proper cell function and connectivity in the nervous system. Researchers have focused on studying MAP2 to gain deeper insights into neuronal development, synaptic plasticity, and neurodegenerative diseases, as its expression and phosphorylation are closely associated with synaptic maturation and neuronal plasticity.

As a cell marker, MAP2 serves as an invaluable marker for identifying neuronal differentiation and assessing neuronal damage or degeneration. This antibody recognizes MAP2 in neuronal cells and can be used as a cell marker antibody when used with a suitable secondary antibody.

Click for more on: cell markers and MAP2
Protein names
Microtubule-associated protein 2 (MAP-2)
Gene names
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Subellular location
Cytoplasm, cytoskeleton Cell projection, dendrite
Interacts with KNDC1 (via KIND2); the interaction enhances MAP2 phosphorylation and localizes KNDC1 to dendrites. Interacts with DPYSL5 (PubMed:33894126).
Post-translational modification
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Target Relevance information above includes information from UniProt accession : P11137
The UniProt Consortium


Immunofluorescent analysis of rat brain stem section stained with goat pAb to MAP2 dilution 1:2,000 in red, and costained with mouse mAb to MBP, dilution 1:5,000, in green. Following transcardial perfusion of rat with 4% paraformaldehyde, brain was post fixed for 24 hours, cut to 45µM, and free-floating sections were stained with above antibodies. The antibody labels MAP2 protein in the perikarya and dendrites of the most neurons, notably motorneurons in the brain stem, and the MBP antibody stains myelin sheath around axons.
Chromogenic immunostaining of a formalin fixed paraffin embedded rat hippocampus section with goat pAb to MAP2 dilution 1:2,000, detected with DAB (brown) using the Vector Elite 8718C-HRP detection and reagents with citra buffer retrieval. Hematoxylin (blue) was used as the counterstain. The antibody labels the MAP2 protein in the somata and dendrites of most neurons. Mouse select image for larger view.
Western blot analysis of whole brain lysates using goat pAb to MAP2 dilution 1:5,000 in green: [1] protein standard (red), [2] rat, and [3] mouse brain lysate. A band at about 280kDa corresponds to the MAP2A and MAP2B proteins.


Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

There are 9 publications in our database for this antibody or clone. Here are the latest 5, for more click below.

35978188Endocytosis in the axon initial segment maintains neuronal polarityEichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K.Nature. 2022 Sep;609(7925):128-135. doi: 10.1038/s41586-022-05074-5. Epub 2022 Aug 17.
22623668An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of RanvierGasser A, Ho TS, Cheng X, Chang KJ, Waxman SG, Rasband MN, Dib-Hajj SD.J Neurosci. 2012 May 23;32(21):7232-43. doi: 10.1523/JNEUROSCI.5434-11.2012.
18988710Gliotypic neural stem cells transiently adopt tumorigenic properties during normal differentiationWalton NM, Snyder GE, Park D, Kobeissy F, Scheffler B, Steindler DA.Stem Cells. 2009 Feb;27(2):280-9. doi: 10.1634/stemcells.2008-0842.
16832065Temporally restricted substrate interactions direct fate and specification of neural precursors derived from embryonic stem cellsGoetz AK, Scheffler B, Chen HX, Wang S, Suslov O, Xiang H, Brüstle O, Roper SN, Steindler DA.Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11063-8. doi: 10.1073/pnas.0510926103. Epub 2006 Jul 10.
16817858Differential modulation of sodium channel Na(v)1.6 by two members of the fibroblast growth factor homologous factor 2 subfamilyRush AM, Wittmack EK, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG.Eur J Neurosci. 2006 May;23(10):2551-62. doi: 10.1111/j.1460-9568.2006.04789.x.


relevant to this product
Western blot


No results found


There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.