ERK1 antibodies

	species	type			applications
1916	mouse	monoclonal (E31R)	IgG1	human	WB
3427	mouse	monoclonal (E19)	IgG1	human mouse	WB
9031	rabbit	polyclonal	IgG	human mouse	WB

ERK1 (Extracellular signal-Regulated Kinase 1) and ERK2 (Extracellular signal-Regulated Kinase 2) are highly conserved members of the mitogen-activated protein kinase (MAPK) family, both playing crucial roles in cellular signaling pathways. They are serine/threonine kinases that become activated in response to a variety of extracellular stimuli, including growth factors, hormones, and stress. Upon activation, ERK1 and ERK2 translocate to the nucleus, where they phosphorylate numerous downstream targets, including transcription factors and other kinases. Through these phosphorylation events, ERK1 and ERK2 regulate a wide range of cellular processes, such as cell proliferation, differentiation, survival, and apoptosis. While they share significant similarities, ERK1 and ERK2 also display distinct functions and differential regulation in certain cellular contexts. Dysregulation of ERK1 and ERK2 signaling has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. Consequently, extensive research continues to focus on elucidating the precise roles of ERK1 and ERK2 in cellular signaling and their potential as therapeutic targets for various pathologies. Understanding the complexity and nuances of ERK1 and ERK2 signaling remains crucial for advancing our knowledge of cellular biology and developing targeted therapies to combat diseases associated with dysregulated MAPK pathways.