Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
host | mouse |
isotype | IgG |
clonality | monoclonal |
concentration | concentrate, predilute |
applications | IHC |
reactivity | human |
available size | 0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted |
rabbit anti-Cytokeratin 20 monoclonal antibody (ZR429) 6144
$160.00 – $528.00
Antibody summary
- Rabbit monoclonal to Cytokeratin 20
- Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
- Reacts with: Human
- Isotype:IgG
- Control: Colon carcinoma
- Visualization: Cytoplasmic
- 0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted
rabbit anti-Cytokeratin 20 monoclonal antibody ZR429 6144
antibody |
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Database link: human P35900 |
Tested applications IHC |
Recommended dilutions As directed |
Immunogen Semi-purified human cytokeratin preparation |
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated |
Form liquid |
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles. |
Purity affinity purified |
Clonality monoclonal |
Isotype IgG |
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720 |
Isotype control Rabbit polyclonal - Isotype Control |
target relevance |
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Protein names Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT) |
Protein family Intermediate filament family |
Mass 48487Da |
Function Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity). . |
Subellular location Cytoplasm . |
Tissues Expressed predominantly in the intestinal epithelium. Expressed in luminal cells of colonic mucosa. Also expressed in the Merkel cells of keratinized oral mucosa; specifically at the tips of some rete ridges of the gingival mucosa, in the basal layer of the palatal mucosa and in the taste buds of lingual mucosa. . |
Structure Heterotetramer of two type I and two type II keratins. Associates with KRT8. |
Post-translational modification PTM: Hyperphosphorylation at Ser-13 occurs during the early stages of apoptosis but becomes less prominent during the later stages. Phosphorylation at Ser-13 also increases in response to stress brought on by cell injury (By similarity). .; PTM: Proteolytically cleaved by caspases during apoptosis. Cleavage occurs at Asp-228. . |
Domain DOMAIN 70..381; /note="IF rod"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01188" |
Target Relevance information above includes information from UniProt accession: P35900 |
The UniProt Consortium |
Data
Human colon carcinoma stained with anti-keratin 20 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of carcinoma glands. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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IHC |
Documents
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Please enter your product and batch number here to retrieve - product datasheet, SDS, and QC information. |
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