Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human pancreatic acinar cell carcinoma stained with anti-CPA1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells

rabbit anti-CPA1 monoclonal antibody (ZR450) 6129

Price range: $160.00 through $528.00

Antibody summary

Rabbit monoclonal to CPA1
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Pancreatic acinar cell carcinoma
Visualization: Secreted and cytoplasmic
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

available sizes

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SKU: 6129parent Category: antibody Tags: anatomy, CPA1, GI Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-CPA1 monoclonal antibody ZR450 6129

antibody
Database link: human P15085
Tested applications IHC
Recommended dilutions Concentrated 1:100-200
Application Notes Positive control: Pancreatic acinar cell carcinoma
Immunogen Recombinant full-length human CPA1 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Carboxypeptidase A1 (EC 3.4.17.1)
Gene names CPA1,CPA1 CPA
Protein family Peptidase M14 family
Mass 47140Da
Function FUNCTION: Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro (PubMed:20385563, PubMed:8806703). Catalyzes the conversion of leukotriene C4 to leukotriene F4 via the hydrolysis of an amide bond (By similarity). {ECO:0000250\|UniProtKB:P00730, ECO:0000269\|PubMed:20385563, ECO:0000269\|PubMed:8806703}.
Catalytic activity CATALYTIC ACTIVITY: Reaction=Release of a C-terminal amino acid, but little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.; EC=3.4.17.1; Evidence={ECO:0000269\|PubMed:20385563, ECO:0000269\|PubMed:8806703}; CATALYTIC ACTIVITY: Reaction=leukotriene C4 + H2O = leukotriene F4 + glycine; Xref=Rhea:RHEA:50740, ChEBI:CHEBI:15377, ChEBI:CHEBI:57305, ChEBI:CHEBI:57973, ChEBI:CHEBI:133618; Evidence={ECO:0000250\|UniProtKB:P00730}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:50741; Evidence={ECO:0000250\|UniProtKB:P00730};
Subellular location SUBCELLULAR LOCATION: Secreted {ECO:0000250\|UniProtKB:Q9UI42}.
Structure SUBUNIT: Monomer. May form a complex with proelastase 2. {ECO:0000269\|PubMed:18566513, ECO:0000269\|PubMed:19179285}.
Target Relevance information above includes information from UniProt accession: P15085
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human pancreatic acinar cell carcinoma stained with anti-CPA1 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.