Immunohistochemistry (IHC) : Formalin-fixed, paraffin-embedded human gastric adenocarcinoma stained with anti-claudin 18.2 antibody using peroxidase-conjugate and DAB chromogen. Note the membranous staining of tumor cells

rabbit anti-Claudin 18.2 monoclonal antibody (ZR451) 6125

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to Claudin 18.2
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG
Control: Carcinomas
Visualization: Cell membrane
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6125parent Category: antibody Tags: anatomy, Claudin 18.2, GI Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-Claudin 18.2 monoclonal antibody ZR451 6125

antibody
Database link: human Q8IZS8
Tested applications IHC
Recommended dilutions As directed
Immunogen Recombinant fragment (around aa1-100) of human Claudin18.2 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Voltage-dependent calcium channel subunit alpha-2/delta-3 (Voltage-gated calcium channel subunit alpha-2/delta-3) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-3; Voltage-dependent calcium channel subunit delta-3]
Protein family Calcium channel subunit alpha-2/delta family
Mass 123011Da
Function The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G) (By similarity).
Subellular location Membrane ; Single-pass type I membrane protein .
Tissues Only detected in brain. Not present in lung, testis, aorta, spleen, jejunum, ventricular muscle and kidney (at protein level). According to PubMed:11687876, it is brain-specific, while according to PubMed:11245980, it is widely expressed.
Structure Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
Post-translational modification PTM: N-glycosylated.; PTM: May be proteolytically processed into subunits alpha-2-3 and delta-3 that are disulfide-linked. It is however unclear whether such cleavage really takes place in vivo and has a functional role (By similarity).
Domain DOMAIN 256..438; /note="VWFA"; /evidence="ECO:0000255\|PROSITE-ProRule:PRU00219"; DOMAIN 452..549; /n
Target Relevance information above includes information from UniProt accession: Q8IZS8
The UniProt Consortium

Data

Formalin-fixed, paraffin-embedded human gastric adenocarcinoma stained with anti-claudin 18.2 antibody using peroxidase-conjugate and DAB chromogen. Note the membranous staining of tumor cells

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.