Immunohistochemistry (IHC) : Human colon adenocarcinoma stained with anti-CDX-2 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells .

rabbit anti-CDX2 monoclonal antibody (ZR215) 6119

$160.00 – $528.00

Antibody summary

Rabbit monoclonal to CDX2
Suitable for: Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Reacts with: Human
Isotype:IgG1
Control: Normal colon or colon adenocarcinoma
Visualization: Nuclear
0.1, 0.5, 1.0 mL concentrated, 7 mL prediluted

SKU: 6119parent Category: antibody Tags: anatomy, CDX2, GI Pathology

Weight	1 lbs
Dimensions	9 × 5 × 2 in
host	mouse
isotype	IgG1
clonality	monoclonal
concentration	concentrate, predilute
applications	IHC
reactivity	human
available size	0.1 mL, 0.5 mL, 1 mL concentrated, 7 mL prediluted

rabbit anti-CDX2 monoclonal antibody ZR215 6119

antibody
Database link: human Q99626
Tested applications IHC
Recommended dilutions As directed
Immunogen Recombinant fragment corresponding to N-terminal of human CDK4 protein
Size and concentration 7 mL prediluted or 0.1, 0.5, 1.0 mL and concentrated
Form liquid
Storage Instructions 2-8°C for short term, for longer term at -20°C. Avoid freeze / thaw cycles.
Purity affinity purified
Clonality monoclonal
Isotype IgG
Compatible secondaries goat anti-rabbit IgG, H&L chain specific, peroxidase conjugated, conjugated polyclonal antibody 9512 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody 2079 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody 7863 goat anti-rabbit IgG, H&L chain specific, Cross Absorbed polyclonal antibody 2371 goat anti-rabbit IgG, H&L chain specific, biotin conjugated polyclonal antibody, crossabsorbed 1715 goat anti-rabbit IgG, H&L chain specific, FITC conjugated polyclonal antibody, crossabsorbed 1720
Isotype control Rabbit polyclonal - Isotype Control

target relevance
Protein names Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
Protein family Caudal homeobox family
Mass 33520Da
Function Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). .
Subellular location Nucleus .
Tissues Detected in small intestine, colon and pancreas. .
Structure Can bind DNA as a monomer or homodimer. .
Post-translational modification PTM: Ubiquitinated, leading to its degradation by the proteasome. .; PTM: Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation. .
Target Relevance information above includes information from UniProt accession: Q99626
The UniProt Consortium

Data

Human colon adenocarcinoma stained with anti-CDX-2 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells .

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.