Dengue Virus superior Human IgM Assay Control BC1141M

$94.00

Summary

Virion/Serion Diagnostic Kit Control for research use (RUO)
Dengue Virus (DENV) superior Human IgM Assay Control, recombinant
Applications: ELISA
Suitable for IgM detection
Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
3 mL

SKU: BC1141M Category: Virion/Serion kits Tags: Dengue Virus, ELISA control serum, IgM

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Dengue Virus superior reactive IgM
species reactivity	Dengue Virus
applications	ELISA
assay type	Indirect & quantitative
available size	1 mL

Dengue Virus superior Human IgM Assay Control BC1141M

kit
Research area Infectious Disease
Storage Store at 2-8°C.
Form liquid
Associated products Dengue Virus superior Human IgM Assay Control (BC1141M) Dengue Virus Human IgM Assay Control (BC114M) Dengue Virus Human IgG Assay Control (BC114G) Dengue Virus superior IgM ELISA Kit (ESR1141M) Dengue Virus IgG ELISA Kit (ESR114G) Dengue Virus IgM ELISA Kit (ESR114M)

target relevance

human antibody anti-Dengue Virus

Dengue Virus

Description
Virus that causes dengue fever and severe dengue

Structure
Dengue virus (DENV) is an enveloped, positive-sense, single-stranded RNA virus belonging to the genus Flavivirus within the family Flaviviridae. Four antigenically distinct serotypes, designated DENV-1, DENV-2, DENV-3, and DENV-4, are capable of causing human disease. The virus is transmitted primarily through the bites of infected Aedes mosquitoes, particularly Aedes aegypti and Aedes albopictus. Following transmission, dengue virus infects dendritic cells, monocytes, macrophages, and other susceptible cells before disseminating throughout the body. Infection with one serotype typically provides long-term immunity against that serotype but only partial and temporary protection against the others. Secondary infection with a different serotype may increase the risk of severe disease through antibody-dependent enhancement (ADE). Dengue virus is one of the most important mosquito-borne viral pathogens worldwide, particularly in tropical and subtropical regions.

Diagnosis
The diagnosis of dengue virus infection is performed through molecular, antigen detection, and serological methods. During the acute phase of illness, reverse transcription polymerase chain reaction (RT-PCR) and detection of the nonstructural protein 1 (NS1) antigen provide sensitive and specific identification of infection. Serological assays, including ELISA-based tests for dengue-specific IgM and IgG antibodies, are commonly used after the acute viremic phase. Interpretation of serological results may be complicated by cross-reactivity with other flaviviruses such as Zika virus, West Nile virus, and Yellow fever virus. Laboratory findings often include leukopenia, thrombocytopenia, elevated liver enzymes, and evidence of increased vascular permeability. Early laboratory confirmation is important for patient monitoring and management.

Symptoms
Dengue virus infection typically develops following an incubation period of approximately four to ten days after the bite of an infected mosquito. Classic dengue fever is characterized by sudden onset of high fever, severe headache, retro-orbital pain, muscle aches, joint pain, fatigue, nausea, vomiting, and a maculopapular rash. The intense muscle and joint pain has led to dengue being nicknamed 'breakbone fever.' Most infections are self-limiting and resolve within one to two weeks. However, a subset of patients develops severe dengue, formerly known as dengue hemorrhagic fever or dengue shock syndrome, characterized by plasma leakage, severe bleeding, thrombocytopenia, organ dysfunction, and circulatory shock. Severe dengue can be life-threatening and requires prompt medical management, particularly in children, elderly individuals, and patients experiencing secondary infection with a different dengue serotype.

Data

FAQ & Publications

Frequently Asked Questions

What is the primary application of the Dengue Virus superior Human IgM Assay Control BC1141M?

This product is primarily used as a control in ELISA assays for the detection of Dengue Virus-specific human IgM antibodies.

How should the Dengue Virus superior Human IgM Assay Control BC1141M be stored to maintain its stability?

The assay control should be stored refrigerated at 2-8°C to preserve its integrity and functionality.

Is the Dengue Virus superior Human IgM Assay Control BC1141M ready to use or does it require dilution?

The control is provided ready-to-use and is pre-diluted specifically for SERION ELISA classic and SERION ELISA antigen assays.

Which species' antibodies does the Dengue Virus superior Human IgM Assay Control BC1141M specifically react with?

This assay control specifically contains human IgM antibodies reactive to Dengue Virus.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
BC1141M protocol

Documents

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Dengue Virus superior Human IgM Assay Control BC1141M

Data

FAQ & Publications

Protocols

Documents

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Reviews

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