| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Bordetella pertussis Toxin |
| species reactivity | Bordetella pertussis (whooping cough) |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available size | 1 mg |
Bordetella pertussis Toxin Antigen BA120VS4
$1,305.00
Summary
- Virion/Serion Immunologics Antigen for research use (RUO)
- Bordetella pertussis Toxin Antigen, recombinant
- Suitable for detection of IgA, IgG & IgM antibodies in ELISA
- Lot specific concentration, specified in mg/mL
- 1 mg
Available on backorder
Bordetella pertussis Toxin Antigen BA120VS4
| kit |
|---|
| Research area Infectious Disease |
| Storage Store at -65°C or lower. Avoid repeated freeze-thaw cycles. Sonicate before use. 10 years from date of manufacture (under recommended storage conditions). |
| Form liquid |
| Associated products Bordetella pertussis Filamentous Hemagglutinin (FHA) Antigen (BA120VS3) Bordetella pertussis Toxin Antigen (BA120VS4) Bordetella pertussis whole cell Antigen (BA120VS8) Bordetella pertussis Toxin Human IgA Assay Control (BC1201A) Bordetella pertussis IgA Control Serum (BC120A) Bordetella pertussis IgG Control Serum (BC120G) Bordetella pertussis Toxin IgA ELISA Kit (ESR1201A) Bordetella pertussis Toxin IgG ELISA Kit (ESR1201G) Bordetella pertussis IgA ELISA Kit (ESR120A) Bordetella pertussis IgG ELISA Kit (ESR120G) Bordetella pertussis IgM ELISA Kit (ESR120M) |
| target relevance |
|---|
| Organism Bordetella pertussis |
| Structure and strains Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. Like B. bronchiseptica, B. pertussis can express a flagellum-like structure, even if it has been historically categorized as a nonmotile bacteria.[1] Its virulence factors include pertussis toxin, adenylate cyclase toxin, filamentous hemagglutinin, pertactin, fimbria, and tracheal cytotoxin. |
| Disease Bordetella pertussis and Bordetella parapertussis are pathogens responsible for whooping cough, a worldwide spread infectious disease that is transmitted from person to person by droplet infection. Often young children up to four years old are affected. The mortality in infected infants is particularly high. Although young people and adults usually do not get seriously ill, they may act as a source of infection for non-protected and at risk patients such as infants and old people. Colonization of the respiratory tract and establishment of infection are facilitated by the synergistic action of several virulence factors. Progression of a typical whooping cough can be divided into three stages. After an incubation period of one to two weeks symptoms begin with the catarrhal phase, usually accompanied by a cough, rhinitis and conjunctivitis. Subsequently, the convulsive phase follows characterized by paroxysmal cough attacks combined with vomiting of viscid mucus, laryngospasm and bronchospasm, leading to cyanosis in the child. After four to six weeks attacks diminish and slowly subside in the decrementi phase. |
| Detection and diagnosis The ELISA technique is the most commonly chosen method for B. pertussis and B. parapertussis specific antibody determination in serodiagnosis and complements direct antigen detection. In over 90% of cases the IgG and IgA antibody responses are directed against the immunogens PT and FHA. Therefore, the SERION ELISA classic Bordetella pertussis IgG and IgA tests are based on antigen mixtures of PT and FHA. For the detection of IgM antibodies cellular bound lipopolysaccharid has outstanding diagnostic properties. Consequently, a whole-cell antigen preparation of B. pertussis is used in the SERION ELISA classic Bordetella pertussis IgM. |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.| pmid | title | authors | citation |
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Protocols
| relevant to this product |
|---|
| BA120VS4 protocol |
Documents
| Product data sheet |
|---|
| BA120VS4 |
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