Ubiquitin antibodies

Ubiquitin is a small regulatory protein that plays a fundamental role in cellular protein degradation through the ubiquitin-proteasome system. By attaching to target proteins, ubiquitin tags them for degradation, ensuring proper turnover of damaged, misfolded, or unneeded proteins. This process is critical for maintaining cellular homeostasis, regulating key biological processes such as cell cycle progression, DNA repair, and response to stress. As a result, ubiquitin is a central player in cellular quality control mechanisms.In Western blotting (WB), ubiquitin is commonly used to study protein degradation, ubiquitination pathways, and the cellular response to stress or disease. The antibodies for ubiquitin offered on your website can also be applied in immunofluorescence (IF) and immunohistochemistry (IHC) to visualize ubiquitinated proteins and their distribution within cells and tissues. This enables researchers to investigate alterations in protein turnover, particularly in conditions like cancer, neurodegenerative diseases, and inflammatory disorders, where the ubiquitin-proteasome system is often dysregulated.Given its role in tagging proteins for degradation and its involvement in diverse cellular processes, ubiquitin serves as an essential marker for studying proteostasis and cellular stress responses. Its significance in research spans many areas, from understanding disease mechanisms to exploring therapeutic targets aimed at modulating protein degradation.