Tick-Borne Encephalitis Virus (TBEV):
Tick-Borne Encephalitis Virus is a member of the Flaviviridae family, and it is primarily transmitted to humans through the bite of infected ticks, particularly Ixodes species. The virus has a single-stranded RNA genome and is categorized into European, Siberian, and Far Eastern subtypes based on geographical distribution.

Diseases caused by Tick-Borne Encephalitis Virus:
Tick-Borne Encephalitis (TBE) is the disease caused by the virus. TBE can manifest as a mild febrile illness, but in some cases, it progresses to a severe neurological form, leading to encephalitis. The severity of the disease varies among the TBEV subtypes. Neurological symptoms include headaches, high fever, neck stiffness, and paralysis. TBE is endemic in certain regions of Europe and Asia, posing a significant public health concern in those areas.

Detection and Diagnosis of Tick-Borne Encephalitis Virus:
Diagnosing TBE involves serological testing to detect specific antibodies produced by the immune system in response to the virus. Enzyme-Linked Immunosorbent Assay (ELISA), such as the assays available here, is a commonly used method for serological diagnosis. In an ELISA, patient serum is applied to a microplate coated with TBEV antigens. If antibodies against the virus are present in the serum, they will bind to the antigens. After washing away unbound components, an enzyme-conjugated secondary antibody is added. The subsequent enzymatic reaction produces a measurable signal, indicating the presence of TBEV-specific antibodies. Molecular methods like PCR can also be employed to detect viral RNA in clinical specimens.