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p16INK4a

p16INK4a: p16INK4a is a cyclin-dependent kinase inhibitor that is commonly used as a marker for cervical intraepithelial neoplasia and cervical cancer. Its overexpression is associated with high-risk human papillomavirus (HPV) infection, making it a crucial diagnostic tool for identifying dysplastic lesions in cervical tissue.



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High grade cervical intraepithelial neoplasia (CINIII) stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of dysplastic cells, whereas the normal squamoujs mucosa is negative.
IHC with antibody [6303] : High grade cervical intraepithelial neoplasia (CINIII) stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of dysplastic cells, whereas the normal squamoujs mucosa is negative.
Invasive cervical squamous cell carcinoma stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of carcinoma cells.
IHC with antibody [6304] : Invasive cervical squamous cell carcinoma stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of carcinoma cells.
Cervical invasive squamous cell carcinoma stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of dysplastic cells.
IHC with antibody [6305] : Cervical invasive squamous cell carcinoma stained with anti-p16 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear and cytoplasmic staining of dysplastic cells.
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