Name: Human Helicobacter IgG Lateral flow dipstick kit 4774
SKU: 4774
Availability: InStock

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Human Helicobacter IgG
species reactivity	Human Helicobacter
applications	Lateral flow (dipstick)
assay type	Indirect & qualitative
available sizes	20 test kits

Human Helicobacter IgG Lateral flow dipstick kit 4774

kit

Assay type
Sandwich assay, lateral flow (dipstick)

Research area
Infectious Disease

Sample type
Serum, plasma, whole blood

Components

10X Wash Buffer	100 mL
TMB Substrate	40 mL
Milk Powder	5 g
Instructions for Use	1 Each
Evaluation Form	1 Each
Test Strips	2 kits of [2 Vials x 10 Each]
Anti-Human IgG Conjugate	500 µL
Positive Control	140 µL
Negative Control	140 µL

Storage
Store at 2-8°C.

Additional information

Mikrogen recomLine Helicobacter 2.0 tests are serological, qualitative in vitro line immunoassays for the detection of antibodies against ten selected Helicobacter pylori antigens. The detection of antibodies against the two most important virulence factors CagA and VacA are of high diagnostic importance. These two virulence factors significantly increase the risk for premalignant changes, gastric carcinoma, MALT lymphoma, and ulcers. Humoral immune responses against the GroEL, HtrA, NapA, HP231, and CtkA biomarkers are associated with more severe disease progression.

Advantages

Sensitivity: > 99% IgG positive results of gold standard positive patients.
Specificity: 100% IgG and IgA negative results of gold standard negative patients.
Excellent correlation with the gold standard of Helicobacter pylori diagnostics - culture and histology.
Reliable results at all times, even with low colonization density.
Identification of highly virulent Helicobacter pylori type I infections using CagA.
Detection of antibodies against ten relevant biomarkers and virulence factors associated with more severe disease progression.
Simple and clear interpretation through easy-to-read banding.
Partial and full automation, software-based evaluation (recomScan), and integration with laboratory information system possible.
Highest sensitivity and specificity through the use of recombinant antigens:

Bands

Antigen	Description	Virulence Factor	Specific for Type I / Type II
CagA	Cytotoxin-associated gene A	Yes	Type I
VacA	Vaculating cytotoxin A	Yes	Type I / Type II
GroEL	Chaperone	No	Type I / Type II
FliD	Flagella hook-associated protein	No	Type I / Type II
HpaA	Neuraminyllactose-binding hemagglutinin, Adhesin	Yes	Type I / Type II
gGT	Gamma-Glutamyl Transpeptidase	Yes<

target relevance
Organism Helicobacter pylori
Protein names Helicobacter pylori
Structure and strains Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, flagellated, helical bacterium. Mutants can have a rod or curved rod shape, and these are less effective. Its helical body (from which the genus name, Helicobacter, derives) is thought to have evolved in order to penetrate the mucous lining of the stomach, helped by its flagella, and thereby establish infection. The bacterium was first identified as the causal agent of gastric ulcers in 1983 by the Australian doctors Barry Marshall and Robin Warren.
Detection and diagnosis In the diagnosis of H. pylori infections, a distinction is made between non-invasive and invasive methods. Invasive procedures contain histology, urease rapid test and microbiological techniques such as cultivation and PCR. The C13-breath test, the Helicobacter pylori antigen detection in stool samples and serological antibody detection based on ELISA or immunoblot belong to the group of non-invasive methods. The detection of serum antibodies can be used for therapy control after eradication therapy

Data

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.