Human Epstein–Barr virus IgG Lateral flow dipstick kit 4572
kit
Assay type Sandwich assay, lateral flow (dipstick)
Research area Infectious Disease
Sample type Serum, plasma, whole blood
Components
10X Wash Buffer
100 mL
TMB Substrate
40 mL
Milk Powder
5 g
Instructions for Use
1 Each
Evaluation Form
1 Each
Test Strips
2 kits of [2 Vials x 10 Each]
Anti-Human IgG Conjugate
500 µL
Positive Control
140 µL
Negative Control
140 µL
Storage Store at 2-8°C.
Additional information
Mikrogen recomLine EBV tests are serological, qualitative in vitro line immunoassays based on recombinantly produced,
highly specific and characteristic EBV antigens. They are designed as screening tests. The line assay technique allows
the detection and identification of IgG and IgM antibodies against the different antigen classes in one approach and at one glance.
Advantages
No disturbing interference with anticellular antibodies.
Patented p18Microgene as additional IgG marker for past infections.
New antigens: Highest sensitivity by BZLF1 in IgG and ZEBRA in IgM detection, in the early phase of acute infections.
In more than 95% of cases, past EBV infections can be correctly identified with the recomLine EBV IgG strip alone.
Simple and meaningful avidity determination - patented.
Separate detection of IgG and IgM antibodies.
Simple and clear interpretation due to easy-to-read banding.
Partial and full automation, software-based evaluation (recomScan), and integration with laboratory information system possible.
Highest sensitivity and specificity through the use of recombinant antigens:
Bands
EBV Antigen Group
Abbreviation
Recombinant Antigen
Size of Recombinant Antigen
Nuclear antigen
EBNA-1
p72
45 kDa
Virus capsid/structural antigen
VCA
p23
23 kDa
Virus capsid/structural antigen
VCA
p18
18 kDa
"Immediate Early Antigen"
IEA
ZEBRA (Peptid)
1.6 kDa
"Immediate Early Antigen"
IEA
BZLF1
30 kDa
"Early Antigen"
EA
p54
54 kDa
"Early Antigen"
EA
p138
40 kDa
target relevance
human antibody anti-Epstein-Barr Virus
Epstein-Barr Virus
Description Virus that causes infectious mononucleosis and is associated with several human cancers
Structure Epstein-Barr virus (EBV), also known as Human herpesvirus 4 (HHV-4), is an enveloped, double-stranded DNA virus belonging to the genus Lymphocryptovirus within the family Herpesviridae. The virus possesses an icosahedral nucleocapsid surrounded by a protein tegument and a lipid envelope containing multiple viral glycoproteins involved in host cell attachment and entry. EBV primarily infects B lymphocytes and epithelial cells and establishes lifelong latent infection following primary exposure. More than 90% of the world's adult population carries the virus. During latency, EBV persists within memory B cells and can periodically reactivate, resulting in viral shedding and transmission. EBV is associated with several malignancies, including Burkitt lymphoma, Hodgkin lymphoma, nasopharyngeal carcinoma, gastric carcinoma, and post-transplant lymphoproliferative disorders.
Diagnosis The diagnosis of Epstein-Barr virus infection is performed through serological, molecular, and hematological methods. Detection of heterophile antibodies using the Monospot test is commonly used for the diagnosis of infectious mononucleosis, although sensitivity may vary depending on age and stage of infection. EBV-specific serological assays measuring antibodies against viral capsid antigen (VCA), early antigen (EA), and Epstein-Barr nuclear antigen (EBNA) provide valuable information regarding acute, past, or reactivated infection. Molecular methods such as quantitative polymerase chain reaction (PCR) are used to detect and monitor viral DNA, particularly in immunocompromised patients and individuals at risk of EBV-associated malignancies. Hematological findings often include atypical lymphocytosis during acute infection.
Symptoms Epstein-Barr virus is primarily transmitted through saliva and is often referred to as the cause of the 'kissing disease.' Following an incubation period of approximately four to six weeks, primary infection may result in infectious mononucleosis characterized by fever, fatigue, sore throat, enlarged lymph nodes, headache, and splenomegaly. Many infections in childhood are asymptomatic or cause only mild illness. Fatigue may persist for weeks or months following acute infection. In immunocompromised individuals, EBV can cause severe lymphoproliferative disease and contribute to the development of certain cancers. Although most infections resolve without complications, rare severe manifestations include hepatitis, neurological complications, hemolytic anemia, and splenic rupture.
Data
FAQ & Publications
Frequently Asked Questions
What sample types are compatible with the Human Epstein–Barr virus IgG Lateral flow dipstick kit 4572?
The kit is compatible with serum, plasma, and whole blood samples for the detection of Epstein–Barr virus IgG antibodies.
How should the Human Epstein–Barr virus IgG Lateral flow dipstick kit 4572 be stored to maintain its stability?
The kit components should be stored at a temperature of 2-8°C to ensure proper stability and performance.
Publications
pmid
title
authors
citation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.
Protocols
relevant to this product
This product has moved to a digital protocol. Please use the URL provided on the product packaging to access the electronic Instructions for Use (eIFU). 4572 protocol
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