| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| target | Tetanus Toxoid |
| species reactivity | Tetanus |
| applications | ELISA |
| assay type | Indirect & quantitative |
| available size | 1 mg |
Tetanus Toxoid Control Antigen BA108VS
$828.00
Summary
- Virion/Serion Diagnostic Kit Control for research use (RUO)
- Tetanus Toxoid Control Antigen, recombinant
- Suitable for detection of IgA, IgG & IgM antibodies in ELISA
- Lot specific concentration, specified in mg/mL
- 1 mg
Available on backorder
Tetanus Toxoid Control Antigen BA108VS
| kit |
|---|
| Assay type Immunoassay |
| Research area Infectious Disease |
| Storage Store at -65°C. Avoid freeze/thaw cycles. Sonicate before use. |
| Form liquid |
| Associated products Tetanus Toxoid Control Antigen (BA108VS) Tetanus IgG Control Serum (BC108G) Tetanus IgG ELISA Kit (ESR108G) |
| target relevance |
|---|
| Organism Tetanus (Clostridium tetani) |
| Structure and strains Clostridium tetani is a common soil bacterium and the causative agent of tetanus. Vegetative cells of Clostridium tetani are usually rod-shaped and up to 2.5 m long, but they become enlarged and tennis racket- or drumstick-shaped when forming spores. C. tetani spores are extremely hardy and can be found globally in soil or in the gastrointestinal tract of animals. If inoculated into a wound, C. tetani can grow and produce a potent toxin, tetanospasmin, which interferes with motor neurons, causing tetanus. The toxin's action can be prevented with tetanus toxoid vaccines, which are often administered to children worldwide. |
| Disease Clostridium tetani is an ubiquitous, obligate anaerobic bacteria. The extremely resistant spores reach the ground through faeces and are able to survive for years. The enters the host by way of contaminated wounds. In the presence of nutrients and anaerobic conditions, spores will convert back to the vegetative form which then produce tetanospasmin, a very potent neurotoxin which causes an increase in neuromuscular stimulation. After an incubation period of a few days up to several weeks, the disease begins with non-specific symptoms, primarily fatigue, followed by characteristic cramps which spread craniofacial to caudal and may also affect the respiratory muscles. Patients are fully conscious during bouts of these extremely painful cramps which may be triggered by the slightest external stimuli. During the course of tetanospasmin poisoning, the patient may suffer from renal, cardiac and circulatory failure. Even with intensive care, over one third of patients die. The safest prophylaxis against tetanus is an active immunization with an effective tetanus toxoid vaccine. Side effects of immunization can occur after multiple vaccinations, varying from local and systemic allergic reactions to anaphylactic shock. |
| Detection and diagnosis To check for the individual's current immune status serological detection of antitoxin IgG antibodies by ELISA techniques are used. Uncertain immune status, possibly due to poor recollection or incomplete documentation, vaccination completions and immune depression, are all indications for performing a confirmatory ELISA to determine antibody levels. Serological investigation with the SERION ELISA classic Tetanus IgG test allows for the precise determination of IgG antibody activities expressed in International Units per milliliter (IU/mL) for direct demonstration of vaccination requirements. |
Publications
| pmid | title | authors | citation |
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| We haven't added any publications to our database yet. | |||
| relevant to this product |
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| BA108VS protocol |
| Product data sheet |
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| BA108VS |
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