Tetanus IgG Control Serum BC108G

$94.00

Summary

Virion/Serion Diagnostic Kit Control for research use (RUO)
Tetanus IgG Control Serum
Applications: ELISA
IgG control serum
Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
3 mL

SKU: BC108G Categories: control serum, Virion/Serion kits Tags: ELISA control serum, IgG, Tetanus

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Tetanus reactive IgG
species reactivity	Tetanus
applications	ELISA
assay type	Indirect & quantitative
available size	3 mL

Tetanus IgG Control Serum BC108G

kit
Research area Infectious Disease
Storage Store at 2-8°C.
Associated products Tetanus Toxoid Control Antigen (BA108VS) Tetanus IgG Control Serum (BC108G) Tetanus IgG ELISA Kit (ESR108G)

target relevance

human antibody anti-Tetanus

Tetanus

Description
Bacterium that causes tetanus (lockjaw)

Structure
Clostridium tetani is a Gram-positive, obligately anaerobic, spore-forming bacterium belonging to the family Clostridiaceae. The organism is widely distributed in soil, dust, and the gastrointestinal tracts of animals and humans. Under unfavorable environmental conditions, C. tetani produces highly resistant endospores that can survive for prolonged periods in the environment. Following contamination of a wound, spores germinate under anaerobic conditions and produce tetanospasmin, a potent neurotoxin responsible for the clinical manifestations of tetanus. The toxin binds to peripheral nerves and travels to the central nervous system, where it blocks inhibitory neurotransmitter release, resulting in uncontrolled muscle contraction and spasm. Although infection does not typically spread beyond the site of entry, the toxin can cause severe systemic disease.

Diagnosis
The diagnosis of tetanus is primarily based on clinical evaluation because laboratory confirmation is often difficult and may not be necessary for treatment decisions. Characteristic symptoms such as muscle rigidity, trismus (lockjaw), and painful muscle spasms in the presence of a compatible wound history strongly support the diagnosis. Isolation of Clostridium tetani from wound specimens is possible but insensitive and not routinely relied upon because the organism may not be recovered even in confirmed cases. Serological testing is generally not useful for diagnosing active disease, although measurement of antitoxin levels may be used to assess immunity. Early recognition is critical because prompt treatment significantly improves outcomes.

Symptoms
Tetanus typically develops following contamination of a wound with Clostridium tetani spores, with an incubation period ranging from several days to several weeks. Early symptoms commonly include jaw stiffness (lockjaw), difficulty swallowing, neck stiffness, irritability, and muscle rigidity. As the disease progresses, painful generalized muscle spasms develop and may be triggered by minor stimuli such as light, sound, or touch. Characteristic manifestations include risus sardonicus (a fixed grimace-like facial expression) and opisthotonos (severe arching of the back). Severe cases may result in respiratory muscle involvement, autonomic nervous system dysfunction, cardiac arrhythmias, respiratory failure, and death. Despite the availability of highly effective vaccines, tetanus remains a significant cause of morbidity and mortality in areas with inadequate immunization coverage.

Data

FAQ & Publications

Frequently Asked Questions

What is the intended application for the Tetanus IgG Control Serum BC108G?

The Tetanus IgG Control Serum BC108G is designed for use in ELISA assays as an IgG control serum, specifically for indirect and quantitative detection.

How should the Tetanus IgG Control Serum BC108G be stored to maintain its stability?

This control serum should be stored at refrigerated temperatures between 2 to 8 degrees Celsius to preserve its integrity.

Is the Tetanus IgG Control Serum BC108G compatible with specific ELISA kits?

Yes, it is ready-to-use and pre-diluted for compatibility with SERION ELISA classic and SERION ELISA antigen assays.

What species reactivity does the Tetanus IgG Control Serum BC108G exhibit?

The control serum specifically targets tetanus reactive IgG and is relevant to tetanus caused by Clostridium tetani.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
BC108G protocol

Documents

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Tetanus IgG Control Serum BC108G

Data

FAQ & Publications

Protocols

Documents

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