Diphtheria IgG Control Serum BC130G

$94.00

Summary

Virion/Serion Diagnostic Kit Control for research use (RUO)
Diphtheria IgG Control Serum
Applications: ELISA
IgG control serum
Ready-to-use; pre-diluted for SERION ELISA classic and SERION ELISA antigen assays
3 mL

SKU: BC130G Categories: control serum, Virion/Serion kits Tags: Diphtheria, ELISA control serum, IgG

Weight	1 lbs
Dimensions	9 × 5 × 2 in
target	Diphtheria reactive IgG
species reactivity	Corynebacterium diphtheriae
applications	ELISA
assay type	Indirect & quantitative
available size	3 mL

Diphtheria IgG Control Serum BC130G

kit
Research area Infectious Disease
Storage Store at 2-8°C.
Associated products Diphtheria Toxoid Control Antigen (BA130VS) Diphtheria IgG Control Serum (BC130G) Corynebacteria dyptheriae IgG ELISA Kit (ESR130G)

target relevance

human antibody anti-Corynebacterium diphtheriae

Corynebacterium diphtheriae

Description
Bacterium that causes diphtheria

Structure
Corynebacterium diphtheriae is a Gram-positive, non-spore-forming, non-motile, aerobic or facultatively anaerobic bacillus belonging to the family Corynebacteriaceae. The organism characteristically appears as club-shaped rods arranged in palisades or angular 'Chinese letter' formations when observed microscopically. C. diphtheriae colonizes the mucous membranes of the upper respiratory tract and, less commonly, the skin. The pathogenicity of the bacterium is primarily determined by its ability to produce diphtheria toxin, a potent exotoxin encoded by a lysogenic bacteriophage. This toxin inhibits protein synthesis within host cells, leading to local tissue necrosis and systemic toxicity. Humans are the principal reservoir of C. diphtheriae, and transmission occurs through respiratory droplets, direct contact with infected individuals, or contact with contaminated materials.

Diagnosis
The diagnosis of Corynebacterium diphtheriae infection is performed through clinical assessment, microbiological culture, and toxin detection methods. Isolation of the organism from throat swabs, nasopharyngeal specimens, or skin lesions on selective media remains an important diagnostic approach. Laboratory identification is followed by testing to determine whether the isolate produces diphtheria toxin, commonly using the Elek immunodiffusion test, polymerase chain reaction (PCR) detection of the tox gene, or other specialized assays. Clinical suspicion is critical because treatment should not be delayed while awaiting laboratory confirmation. Additional laboratory findings may include elevated inflammatory markers and evidence of organ involvement in severe cases.

Symptoms
Diphtheria typically develops following an incubation period of two to five days. Respiratory diphtheria commonly presents with sore throat, fever, malaise, difficulty swallowing, and cervical lymphadenopathy. A characteristic gray-white pseudomembrane may form on the tonsils, pharynx, or larynx and can cause airway obstruction if extensive. Neck swelling resulting from severe lymphadenopathy and soft tissue edema may produce the classic 'bull neck' appearance. Systemic absorption of diphtheria toxin can lead to myocarditis, cardiac arrhythmias, heart failure, peripheral neuropathy, cranial nerve dysfunction, and paralysis. Cutaneous diphtheria presents as chronic skin ulcers covered by a gray membrane. Without prompt treatment, severe diphtheria can result in respiratory failure, multi-organ complications, and death.

Data

FAQ & Publications

Frequently Asked Questions

What is the primary application of the Diphtheria IgG Control Serum BC130G?

The Diphtheria IgG Control Serum BC130G is primarily used as a control serum in ELISA assays, specifically for the SERION ELISA classic and SERION ELISA antigen tests targeting diphtheria IgG antibodies.

How should the Diphtheria IgG Control Serum BC130G be stored to maintain its stability?

This control serum should be stored at temperatures between 2-8°C to ensure its stability and suitability for research use.

Is the Diphtheria IgG Control Serum BC130G ready to use, or does it require dilution before application?

The serum is provided ready-to-use and is pre-diluted for compatibility with SERION ELISA classic and SERION ELISA antigen assays, eliminating the need for further dilution.

Which organism's IgG antibodies does the Diphtheria IgG Control Serum BC130G specifically target?

The control serum targets IgG antibodies reactive to Corynebacterium diphtheriae, the pathogenic bacterium responsible for diphtheria infection.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from the PubMed database provided by the United States National Library of Medicine at the National Institutes of Health.

Protocols

relevant to this product
BC130G protocol

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Diphtheria IgG Control Serum BC130G

Data

FAQ & Publications

Protocols

Documents

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