Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein 3351

$375.00 – $1,250.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Phe31-Pro993(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail

available size

Clear

SKU: 3351parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	F6QSK2(ITGAV)&A0A1D5QZT0(ITGB6)
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
molecular weight	The protein has a predicted MW of 112.1 kDa (ITGAV) and 79 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-140 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein 3351

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Protein names Integrin subunit alpha V
Gene names ITGAV,ITGAV
Protein family Integrin alpha chain family
Mass 116488Da
Subellular location Membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: F6QSK2
The UniProt Consortium

Data

ELISA with Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterod

Immobilized Rhesus macaque ITGAV&ITGB6, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-alpha-V Antibody, hFc Tag with the EC50 of 10.6ng/ml determined by ELISA.

HPLC of Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodime

The purity of Rhesus macaque ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Rhesus macaque Integrin alpha V beta 6 (ITGAV&ITGB6) He

Rhesus macaque ITGAV&ITGB6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.