Rat XPNPEP2 Protein 2891

$345.00 – $1,150.00

Summary

Expression: HEK293
Active: Yes (catalytic)
Amino Acid Range: Pro23-Ala650

SKU: 2891parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q99MA2
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.
molecular weight	The protein has a predicted MW of 72.05 kDa. Due to glycosylation, the protein migrates to 75-85 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Rat XPNPEP2 Protein 2891
protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.
Protein names
Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (mAPP) (X-prolyl aminopeptidase 2)
Gene names
Xpnpep2,Xpnpep2
Protein family
Peptidase M24B family
Mass
10116Da
Function
Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin.
Catalytic activity
BINDING 116; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 430; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 450; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 461; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 461; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 524; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 524; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 533; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 555; /ligand="substrate"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 555; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 569; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="1"; /evidence="ECO:0000250|UniProtKB:O44750"; BINDING 569; /ligand="Zn(2+)"; /ligand_id="ChEBI:CHEBI:29105"; /ligand_label="2"; /evidence="ECO:0000250|UniProtKB:O44750"
Subellular location
Cell membrane ; Lipid-anchor, GPI-anchor .
Tissues
Expressed strongly in lung, liver and heart, and at lower levels in kidney, testis, brain, spleen and skeletal muscle.
Structure
Homotrimer.
Post-translational modification
N-glycosylated.
Target Relevance information above includes information from UniProt accession: Q99MA2
The UniProt Consortium

Measured by its ability to cleave the fluorogenic peptide substrate, H-Lys(2-Aminobenzoyl)-Pro-Pro-p-Nitroanilide (K(Abz)PP-pNA). The specific activity is > 400 pmol/min/µg.

The purity of Rat XPNPEP2 is greater than 95% as determined by SEC-HPLC.

Rat XPNPEP2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.