Rat XPNPEP2 Protein 2891

$345.00 – $1,150.00

Summary

Expression: HEK293
Active: Yes (catalytic)
Amino Acid Range: Pro23-Ala650

SKU: 2891parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q99MA2
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.
molecular weight	The protein has a predicted MW of 72.05 kDa. Due to glycosylation, the protein migrates to 75-85 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Rat XPNPEP2 Protein 2891

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Aminopeptidase P2 (XPNPEP2) is a receptor for TMTP1 tumor-homing peptide. However, the biological and clinical significance of Aminopeptidase P2 in human cancers remains unknown.
Protein names Xaa-Pro aminopeptidase 2 (EC 3.4.11.9) (Membrane-bound aminopeptidase P) (Membrane-bound APP) (mAPP) (X-prolyl aminopeptidase 2)
Gene names Xpnpep2,Xpnpep2
Protein family Peptidase M24B family
Mass 76080Da
Function FUNCTION: Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin. {ECO:0000269\|PubMed:7669781}.
Catalytic activity CATALYTIC ACTIVITY: Reaction=Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.; EC=3.4.11.9; Evidence={ECO:0000269\|PubMed:7669781};
Subellular location SUBCELLULAR LOCATION: Cell membrane {ECO:0000305\|PubMed:7669781}; Lipid-anchor, GPI-anchor {ECO:0000269\|PubMed:7669781}.
Tissues TISSUE SPECIFICITY: Expressed strongly in lung, liver and heart, and at lower levels in kidney, testis, brain, spleen and skeletal muscle. {ECO:0000269\|PubMed:12941294}.
Structure SUBUNIT: Homotrimer. {ECO:0000250\|UniProtKB:Q95333}.
Post-translational modification PTM: N-glycosylated. {ECO:0000269\|PubMed:7669781}.
Target Relevance information above includes information from UniProt accession: Q99MA2
The UniProt Consortium

Data

Measured by its ability to cleave the fluorogenic peptide substrate, H-Lys(2-Aminobenzoyl)-Pro-Pro-p-Nitroanilide (K(Abz)PP-pNA). The specific activity is > 400 pmol/min/µg.

The purity of Rat XPNPEP2 is greater than 95% as determined by SEC-HPLC.

Rat XPNPEP2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.