Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | A6JXD6 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. |
molecular weight | The protein has a predicted MW of 20.39 kDa. Due to glycosylation, the protein migrates to 28-38 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Rat CD40/TNFRSF5 Protein 2084
$240.00 – $800.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Val24-Arg193
Rat CD40/TNFRSF5 Protein 2084
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. |
Protein names Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) |
Gene names Cd40,Cd40 |
Mass 10116Da |
Subellular location Membrane ; Single-pass type I membrane protein . |
Target Relevance information above includes information from UniProt accession: A6JXD6 |
The UniProt Consortium |
Data
The purity of Rat CD40 is greater than 95% as determined by SEC-HPLC. |
Rat CD40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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