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Rat CD40/TNFRSF5 Protein 2084

$240.00$800.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Val24-Arg193
SKU: 2084parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A6JXD6

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.

molecular weight

The protein has a predicted MW of 20.39 kDa. Due to glycosylation, the protein migrates to 28-38 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Rat CD40/TNFRSF5 Protein 2084

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
Protein names
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor)
Gene names
Cd40,Cd40
Mass
10116Da
Subellular location
Membrane ; Single-pass type I membrane protein .
Target Relevance information above includes information from UniProt accession: A6JXD6
The UniProt Consortium

Data

HPLC of Rat CD40/TNFRSF5 Protein
The purity of Rat CD40 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Rat CD40/TNFRSF5 Protein
Rat CD40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

relevant to this product

Documents

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