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Mouse TREML2/TLT-2 Protein 3575

$330.00$1,100.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: His25-Ala270
SKU: 3575parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q2LA85

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

As an important family member of triggering receptor expressed on myeloid cells (TREM), TREM-like transcript 2 gene (TREML2) locates on human chromosome 6p21.1, a newly-identified hot zone for AD susceptibility, and encodes atransmembrane immune receptor. Emerging evidence implied a potential role of TREML2 in the susceptibility and pathogenesis of AD.

molecular weight

The protein has a predicted MW of 28.6 kDa. Due to glycosylation, the protein migrates to 73-80 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse TREML2/TLT-2 Protein 3575

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
As an important family member of triggering receptor expressed on myeloid cells (TREM), TREM-like transcript 2 gene (TREML2) locates on human chromosome 6p21.1, a newly-identified hot zone for AD susceptibility, and encodes atransmembrane immune receptor. Emerging evidence implied a potential role of TREML2 in the susceptibility and pathogenesis of AD.
Protein names
Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2)
Gene names
Treml2,Treml2 Tlt2
Mass
10090Da
Function
Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity).
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
Detected in B-lymphocytes and macrophages. Detected in spleen, lymph nodes, blood, bone marrow and cells from the peritoneal cavity (at protein level).
Structure
Interacts with CD276 and this interaction enhances T-cell activation.
Target Relevance information above includes information from UniProt accession: Q2LA85
The UniProt Consortium

HPLC of Mouse TREML2/TLT-2 Protein
The purity of Mouse TREML2/TLT-2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse TREML2/TLT-2 Protein
Mouse TREML2/TLT-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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