Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q2LA85 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | As an important family member of triggering receptor expressed on myeloid cells (TREM), TREM-like transcript 2 gene (TREML2) locates on human chromosome 6p21.1, a newly-identified hot zone for AD susceptibility, and encodes atransmembrane immune receptor. Emerging evidence implied a potential role of TREML2 in the susceptibility and pathogenesis of AD. |
molecular weight | The protein has a predicted MW of 28.6 kDa. Due to glycosylation, the protein migrates to 73-80 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse TREML2/TLT-2 Protein 3575
$330.00 – $1,100.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: His25-Ala270
Mouse TREML2/TLT-2 Protein 3575
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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As an important family member of triggering receptor expressed on myeloid cells (TREM), TREM-like transcript 2 gene (TREML2) locates on human chromosome 6p21.1, a newly-identified hot zone for AD susceptibility, and encodes atransmembrane immune receptor. Emerging evidence implied a potential role of TREML2 in the susceptibility and pathogenesis of AD. |
Protein names Trem-like transcript 2 protein (TLT-2) (Triggering receptor expressed on myeloid cells-like protein 2) |
Gene names Treml2,Treml2 Tlt2 |
Mass 10090Da |
Function Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity). |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Detected in B-lymphocytes and macrophages. Detected in spleen, lymph nodes, blood, bone marrow and cells from the peritoneal cavity (at protein level). |
Structure Interacts with CD276 and this interaction enhances T-cell activation. |
Target Relevance information above includes information from UniProt accession: Q2LA85 |
The UniProt Consortium |
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The purity of Mouse TREML2/TLT-2 is greater than 95% as determined by SEC-HPLC. |
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Mouse TREML2/TLT-2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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