Mouse Syndecan-1 Protein 3546

$315.00 – $1,050.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gln23-Gly255

SKU: 3546parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P18828
express system	HEK293
product tag	C-hFc
purity	> 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.
molecular weight	The protein has a predicted MW of 51 kDa. Due to glycosylation, the protein migrates to 85-110 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse Syndecan-1 Protein 3546

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Liver diseases such as liver cirrhosis, primary and metastatic liver cancers are still a major medical challenge. Syndecan-1 is one of the most important proteoglycans in the liver. Syndecan-1 is normally expressed on the surfaces of hepatocytes and cholangiocytes. Due to liver diseases the amount of syndecan-1 increases in the liver.
Protein names Syndecan-1 (SYND1) (CD antigen CD138)
Gene names Sdc1,Sdc1 Synd-1 Synd1
Protein family Syndecan proteoglycan family
Mass 10090Da
Function Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (PubMed:8163535). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217).
Subellular location Membrane ; Single-pass type I membrane protein. Secreted. Secreted, extracellular exosome. Note=Shedding of the ectodomain produces a soluble form.
Structure Interacts with CDCP1 (By similarity). Interacts (via C-terminus) with TIAM1 (via PDZ domain) (PubMed:20361982). Interacts with MDK (By similarity).
Post-translational modification Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Target Relevance information above includes information from UniProt accession: P18828
The UniProt Consortium

The purity of Mouse Syndecan-1 is greater than 90% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse Syndecan-1 Protein

Mouse Syndecan-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.