Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q8C310 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Roundabout (Robo) family of axon guidance molecules. Robo4 is an endothelial-specific receptor that participates in endothelial cell migration, proliferation, and angiogenesis and the maintenance of vasculature homeostasis. Robo4 is a promising and potentially valuable therapeutic target for treating pathological angiogenesis and developmental defects in angiogenesis. |
molecular weight | The protein has a predicted MW of 50.3 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse ROBO4 Protein 3996
$285.00 – $950.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Leu28-Trp480
Mouse ROBO4 Protein 3996
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Roundabout4 (Robo4) is a transmembrane receptor that belongs to the Roundabout (Robo) family of axon guidance molecules. Robo4 is an endothelial-specific receptor that participates in endothelial cell migration, proliferation, and angiogenesis and the maintenance of vasculature homeostasis. Robo4 is a promising and potentially valuable therapeutic target for treating pathological angiogenesis and developmental defects in angiogenesis. |
Protein names Roundabout homolog 4 |
Gene names Robo4,Robo4 |
Protein family Immunoglobulin superfamily, ROBO family |
Mass 10090Da |
Function Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity). |
Tissues Expressed specifically in embryo and adult vascular endothelium. |
Structure Interacts with SLIT2 and ENAH. |
Target Relevance information above includes information from UniProt accession: Q8C310 |
The UniProt Consortium |
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The purity of Mouse ROBO4 is greater than 95% as determined by SEC-HPLC. |
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Mouse ROBO4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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