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Mouse Nectin-4 Protein 4771

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gly31-Ser347
SKU: 4771parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q8R007

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.

molecular weight

The protein has a predicted MW of 35.4 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse Nectin-4 Protein 4771

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus.
Protein names
Nectin-4 (Ig superfamily receptor LNIR) (Nectin cell adhesion molecule 4) (Poliovirus receptor-related protein 4)
Gene names
Nectin4,Nectin4 Lnir Prr4 Pvrl4
Protein family
Nectin family
Mass
10090Da
Function
FUNCTION: Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. {ECO:0000250}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q96NY8}.
Tissues
TISSUE SPECIFICITY: Expressed in brain, lung, testis and embryo. {ECO:0000269|PubMed:11544254}.
Structure
SUBUNIT: Self-associates. Interacts via its Ig-like V-type domain with NECTIN1 Ig-like V-type domain. Interacts via its C-terminus with AFDN (By similarity). {ECO:0000250}.
Target Relevance information above includes information from UniProt accession : Q8R007
The UniProt Consortium

Data

ELISA with Mouse Nectin-4 Protein
Immobilized Mouse Nectin-4, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human Nectin-1, hFc Tag with the EC50 of 0.16µg/ml determined by ELISA.
HPLC of Mouse Nectin-4 Protein
The purity of Mouse Nectin-4 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse Nectin-4 Protein
Mouse Nectin-4 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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