Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q8R2Y2 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells. |
molecular weight | The protein has a predicted MW of 60.9 kDa. Due to glycosylation, the protein migrates to 75-95 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse MUC18/CD146 Protein 3655
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Val24-Val563
Mouse MUC18/CD146 Protein 3655
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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METCAM/MUC18 is an integral membrane cell adhesion molecule (CAM) in the Ig-like gene super-family. It can carry out common functions of CAMs which is to perform intercellular interactions and interaction of cell with extracellular matrix in tumor microenvironment, to interact with various signaling pathways and to regulate general behaviors of cells.The above positive correlation is fortuitous; actually METCAM/MUC18 acts as a tumor and metastasis suppressor for the ovarian carcinoma cells. |
Protein names Cell surface glycoprotein MUC18 (Gicerin) (Melanoma cell adhesion molecule) (Melanoma-associated antigen MUC18) (CD antigen CD146) |
Gene names Mcam,Mcam Muc18 |
Mass 10090Da |
Function Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity). |
Subellular location Membrane ; Single-pass type I membrane protein . |
Tissues Detected in melanoma cell lines. |
Target Relevance information above includes information from UniProt accession: Q8R2Y2 |
The UniProt Consortium |
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The purity of Mouse MUC18 is greater than 95% as determined by SEC-HPLC. |
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Mouse MUC18 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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