Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q9Z0T9 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. |
molecular weight | The protein has a predicted MW of 75.7 kDa. Due to glycosylation, the protein migrates to 80-115 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse ITGB6 Protein 4342
$330.00 – $1,100.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Gly22-Asn706
Mouse ITGB6 Protein 4342
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. |
Protein names Integrin beta-6 |
Gene names Itgb6,Itgb6 |
Protein family Integrin beta chain family |
Mass 86042Da |
Function Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398). |
Subellular location Cell membrane ; Single-pass type I membrane protein. Cell junction, focal adhesion . |
Structure Heterodimer of an alpha and a beta subunit (PubMed:10025398). Interacts with FLNB (By similarity). Interacts with HAX1 (By similarity). ITGAV:ITGB6 interacts with FBN1 (By similarity). ITGAV:ITGB6 interacts with TGFB1 (PubMed:10025398). |
Domain The VWFA domain (or beta I domain) contains three cation-binding sites: the ligand-associate |
Target Relevance information above includes information from UniProt accession: Q9Z0T9 |
The UniProt Consortium |
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The purity of Mouse ITGB6 is greater than 95% as determined by SEC-HPLC. |
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Mouse ITGB6 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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