Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein 3151

$375.00 – $1,250.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail

available size

Clear

SKU: 3151parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P24063(ITGAL)&P11835(ITGB2)
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM1/CD54, ICAM2, ICAM3 and JAM1[2].
molecular weight	The protein has a predicted MW of 123.30 kDa (ITGAL) and 79.60 kDa (ITGB2). Due to glycosylation, the protein migrates to 160-180 kDa (ITGAL) and 90-105 kDa (ITGB2) based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein 3151

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM1/CD54, ICAM2, ICAM3 and JAM1[2].
Protein names Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (Lymphocyte antigen 15) (Ly-15) (CD antigen CD11a)
Gene names Itgal,Itgal Lfa-1 Ly-15
Protein family Integrin alpha chain family
Mass 128314Da
Function Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:2051027). Integrin ITGAL/ITGB2 is a receptor for F11R (By similarity). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:16234355, PubMed:24158516). Required for generation of common lymphoid progenitor cells in bone marrow, indicating the role in lymphopoiesis (PubMed:25108025). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages.
Subellular location Cell membrane ; Single-pass type I membrane protein .
Tissues Leukocytes.
Structure Heterodimer of an alpha and a beta subunit. The ITGAL alpha subunit associates with the ITGB2 beta subunit. Interacts with THBD.
Post-translational modification In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for the activation by some physiological agents.
Domain The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo pro
Target Relevance information above includes information from UniProt accession: P24063
The UniProt Consortium

Data

HPLC of Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer Protein

The purity of Mouse ITGAL&ITGB2 is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer

Mouse ITGAL&ITGB2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.