Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | NP_032398.3 |
express system | HEK293 |
product tag | C-hFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth. |
molecular weight | The protein has a predicted MW of 51.74 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse IL-7R alpha/CD127 Protein 3290
$270.00 – $900.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Glu21-Asp239
Mouse IL-7R alpha/CD127 Protein 3290
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Interleukin 7 (IL-7) and its receptor (IL-7R, a heterodimer of IL-7Rα and γc) are essential for normal lymphoid development. IL-7 and IL-7R activate three main pathways: STAT5, PI3K/Akt/mTOR and MEK/Erk, ultimately leading to the promotion of leukemia cell viability, cell cycle progression and growth. |
Protein names Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) |
Protein family Type I cytokine receptor family, Type 4 subfamily |
Mass 51579Da |
Function Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
Subellular location [Isoform 1]: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:31748347}.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted. |
Structure The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Interacts with CD53 (PubMed:31748347). {ECO:0000269|PubMed:19141282, ECO:0000269|PubMed:31748347}. |
Post-translational modification N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. {ECO:0000269|PubMed:19141282}. |
Domain The WSXWS motif appears to be necessary for proper protein folding and thereby efficient int |
Target Relevance information above includes information from UniProt accession: P16871 |
The UniProt Consortium |
Publications
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