Mouse IL-5 R alpha/CD125 Protein 4092

$210.00 – $700.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Asp18-His339

SKU: 4092parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P21183
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Interleukin‑5 Receptor alpha (IL‑5 R alpha), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology.This is the receptor for interleukin-5. The alpha chain binds to IL5.
molecular weight	The protein has a predicted MW of 37.7 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse IL-5 R alpha/CD125 Protein 4092

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Interleukin-5 Receptor alpha (IL-5 R alpha), also known as CD125, is a 60 kDa hematopoietin receptor that plays a dominant role in eosinophil biology.This is the receptor for interleukin-5. The alpha chain binds to IL5.
Protein names
Interleukin-5 receptor subunit alpha (IL-5 receptor subunit alpha) (IL-5R subunit alpha) (IL-5R-alpha) (IL-5RA) (CD antigen CD125)
Gene names
Il5ra,Il5ra Il5r
Mass
10090Da
Function
Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:1873482). Acts by forming an heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway.
Subellular location
Membrane; Single-pass type I membrane protein.
Tissues
Expressed on eosinophils and basophils. Also on B-cells.
Structure
Interacts with IL5 (PubMed:1873482). Interacts with CSF2RB. Interacts with JAK2. Interacts with SDCBP.
Domain
Th
Target Relevance information above includes information from UniProt accession: P21183
The UniProt Consortium

Data

SPR with Mouse IL-5 R alpha/CD125 Protein

Mouse IL-5 R alpha, His Tag immobilized on CM5 Chip can bind Mouse IL-5, His Tag with an affinity constant of 0.495 µM as determined in SPR assay (Biacore T200).

HPLC of Mouse IL-5 R alpha/CD125 Protein

The purity of Mouse IL-5 R alpha is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse IL-5 R alpha/CD125 Protein

Mouse IL-5 R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.