Mouse IL-18BP Protein 3986

$120.00 – $400.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Thr29-Ala193

SKU: 3986parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9Z0M9
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer, components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
molecular weight	The protein has a predicted MW of 19.1 kDa. Due to glycosylation, the protein migrates to 45-65 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse IL-18BP Protein 3986

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Cytokines were the first modern immunotherapies to produce durable responses in patients with advanced cancer,components of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesting that IL-18 therapy could enhance anti-tumour immunity. IL-18BP, a high-affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limits the anti-tumour activity of IL-18 in mice.
Protein names Interleukin-18-binding protein (IL-18BP) (Interferon gamma-inducing factor-binding protein)
Gene names Il18bp,Il18bp Igifbp
Mass 10090Da
Function Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).
Subellular location Secreted .
Target Relevance information above includes information from UniProt accession: Q9Z0M9
The UniProt Consortium

Mouse IL-18BP, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 0.86 nM as determined in SPR assay (Biacore T200).

Immobilized Mouse IL-18BP, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated IL-18, No Tag with the EC50 of 23.8ng/ml determined by ELISA (QC Test).

Mouse IL-18BP on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.