Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P01572 |
express system | HEK293 |
product tag | C-hFc |
purity | > 95% as determined by Tris-Bis PAGE |
background | IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
molecular weight | The protein has a predicted MW of 45.88 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse IFN alpha 1 Protein 3180
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Binding assay: Yes (SPR)
- Amino Acid Range: Cys24-Lys189
Mouse IFN alpha 1 Protein 3180
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. |
Protein names Interferon alpha-1 (IFN-alpha-1) |
Gene names Ifna1,Ifna1 |
Protein family Alpha/beta interferon family |
Mass 10090Da |
Function Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. |
Subellular location Secreted. |
Post-translational modification Glycosylated. |
Target Relevance information above includes information from UniProt accession: P01572 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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